ArticleBioactive materials2022
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Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Magnesium Alloys in Orthopedics: A Systematic Review on Approaches, Coatings and Strategies to Improve Biocompatibility, Osteogenic Properties and Osteointegration Capabilities.International journal of molecular sciences · 2023Pooled it
- Magnesium and nerve injury: Mechanisms and applications.Neural regeneration research · 2026Article
- Paired CycleGAN-based virtual staining for 3D X-ray histology of bone-implant systems.Journal of synchrotron radiation · 2026Article
- Computational modelling of bone growth and mineralization surrounding biodegradable Mg-based and permanent Ti implants.Computational and structural biotechnology journal · 2025Article
- Best Practices in Developing a Workflow for Uncertainty Quantification for Modeling the Biodegradation of Mg-Based Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multi-modal investigation of the bone micro- and ultrastructure, and elemental distribution in the presence of Mg-xGd screws at mid-term healing stages.Bioactive materials · 2024Article
- An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion.Bioactive materials · 2024Review
- Sheep Bone Ultrastructure Analyses Reveal Differences in Bone Maturation around Mg-Based and Ti Implants.Journal of functional biomaterials · 2024Article
- Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants.Bioactive materials · 2023Article
- Local Structural Modifications in Metallic Micropillars Induced by Plasma Focused Ion Beam Processing.Materials (Basel, Switzerland) · 2023Article
- Comparison of Resorbable and Non-Resorbable Osteosynthesis Material in Hallux Surgery: A Systematic Review.Life (Basel, Switzerland) · 2023Review
- On the material dependency of peri-implant morphology and stability in healing bone.Bioactive materials · 2023Article
- Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study.Bioactive materials · 2023Article
- Degradation behavior of ZE21C magnesium alloy suture anchors and their effect on ligament-bone junction repair.Bioactive materials · 2023Article
- Degradation behavior and osseointegration of Mg-Zn-Ca screws in different bone regions of growing sheep: a pilot study.Regenerative biomaterials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biodegradable magnesium (Mg) alloys can revolutionize osteosynthesis, because they have mechanical properties similar to those of the bone, and degrade over time, avoiding the need of removal surgery. However, they are not yet routinely applied because their degradation behavior is not fully understood. In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium (Gd) at high resolution. Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4, 8 and 12 weeks. Afterward, the degradation rate and degradation homogeneity, as well as bone-to-implant interface, were studied with synchrotron radiation micro computed tomography and histology. Titanium (Ti) and polyether ether ketone (PEEK) were used as controls material to evaluate osseointegration. Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd. Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue. The results were correlated to
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.