ArticleHealth science reports2022
The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea.
Article in Health science reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Diabetes is associated with elevated mortality, stroke, and osteoradionecrosis in squamous cell carcinomas of the head and neck: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Associations of a previous diagnosis of cancer and/or cardiovascular disease with current physical activity levels in Korean adults.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Scoping review of the use of multimorbidity variables in cardiovascular disease risk prediction.BMC public health · 2025Article
- Evaluation of the Relationship Between Water Hardness and Incidence of Cardiovascular Diseases in Mashhad, Iran During 2018-2020: A Cross-Sectional Study.Health science reports · 2025Article
- Article
- Stroke Risk in Survivors of Head and Neck Cancer.JAMA network open · 2024Article
- The risk of cardiovascular disease and stroke in survivors of head and neck cancer in Korea.Health science reports · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHead and neck cancer (HNCA) survivors have a high risk of developing cardiovascular disease (CVD) or stroke because of sharing risk factors of disease. Therefore, we investigated the risk of CVD or stroke occurrence among HNCA survivors in Korea based on the Health Insurance Review and Assessment (HIRA) Service claims database.
methodsWe retrieved claims data of patients who were diagnosed with HNCA in 2014-2015 using ICD-10 code and followed up data until 2018. Patients with newly diagnosed with CVD or stroke after HNCA diagnosis during the follow-up period were detected. We analyzed the characteristics of patients with HNCA who were subsequently diagnosed with CVD or stroke. In addition, the risk factors of CVD or stroke occurrence were investigated using Cox proportional hazard regression analysis.
resultsAmong the 8288 patients with HNCA, 477 and 404 patients were diagnosed with new-onset CVD and stroke, respectively. Patients with hypertension, diabetes mellitus (DM), and hyperlipidemia had a 3.25-fold higher risk of CVD comparing to patients without any underlying disease (95% confidence index [CI], 2.38-4.45) Patients with three underlying diseases had a 2.92-fold higher risk of stroke compared to patients without any underlying disease (95% CI 2.03-4.21).
conclusionsHNCA survivors with hypertension, DM, and hyperlipidemia should be cautious of the risks of CVD and stroke.
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Registered trials
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