Evidence map›Paper›PMID 35224110›Full record

ArticleJournal of immunology research2022

The Expression and Clinical Significance of PCNAP1 in Hepatocellular Carcinoma Patients.

Yanhong Chen, Jiao Zhang, Jia Liu, Jianguo Wang, Chao Shi, Lu Lu, Xing Cheng, Guoping Niu, Shuangshuang Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Combinatorial Gene Expression Profiling of SerumInternational journal of molecular sciences · 2024
    Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yanhong ChenDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Jiao ZhangDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Jia LiuDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Jianguo WangDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Chao ShiDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Lu LuDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Xing ChengDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.
Guoping NiuDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.ORCID https://orcid.org/0000-0002-9289-8166
Shuangshuang ZhangDepartment of Clinical Laboratory, Xuzhou Central Hospital, China.ORCID https://orcid.org/0000-0002-6034-699X
Xuzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong noncoding RNAs (lncRNAs) play an important role in many cancer progression. The aim of this study was to evaluate the expression level and clinical significance of the lncRNA, proliferating cell nuclear antigen pseudogene 1 (PCNAP1), in cancer tissue and the plasma of patients with hepatocellular carcinoma (HCC).

methodsQuantitative real-time polymerase chain reaction was used to detect the expression of PCNAP1 in HCC tissue, adjacent tissue, and plasma. Spearman's rank correlation analysis was performed to assess relationships among cancer tissue, plasma PCNAP1, and plasma AFP. Kaplan-Meier analysis was used to assess survival of HCC patient with high and low expression of PCNAP1. The survival difference was compared by the log-rank test. The use of plasma levels PCNAP1 for diagnosing HCC was evaluated by receiver operating characteristic curve analysis.

resultsThe expression of PCNAP1 in HCC tissue was significantly higher than in adjacent tissue (

conclusionThis study demonstrates PCNAP1 levels to be increased in HCC patients. As such, PCNAP1 may be a new tool useful in disease diagnosis and prognosis.

Indexed as

AgedAged, 80 and overBiomarkers, TumorCarcinoma, HepatocellularFemaleGene Expression Regulation, NeoplasticHumansLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPrognosisRNA, Long NoncodingSensitivity and SpecificitySurvival AnalysisBiomarkers, TumorRNA, Long Noncoding

Identifiers

PMID35224110
PMCPMC8881134
OpenAlexW4213136617

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.