ReviewFrontiers in cardiovascular medicine2022
Why Are Women Predisposed to Intracranial Aneurysm?
Review in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Risk factors for saccular unruptured intracranial aneurysms: a systematic review and meta-analysis.European stroke journal · 2026Pooled it
- Underreporting of Sex-Specific Findings in Risk Factors for Unruptured Intracranial Aneurysms.Cerebrovascular diseases (Basel, Switzerland) · 2026Pooled it
- Baseline demographic and aneurysm morphologic features associated with woven endobridge angiographic outcomes: A systematic review and meta-analysis.Neuroradiology · 2025Pooled it
- Association between possible osteopenia and the growth of small unruptured intracranial aneurysms.Neurosurgical review · 2026Article
- Hemodynamic Stress as a Cause of the High Prevalence of Arterial Disease in Women.Journal of vascular research · 2026Review
- Subarachnoid hemorrhage: epidemiology, risk factors, pathogenesis, and clinical therapies.Molecular biomedicine · 2026Review
- Cortical thinning and volumetric alterations in patients with unruptured intracranial aneurysms: insights from surface-based morphometry.Neurosurgical review · 2026Article
- Effects of 12-week 24-form Tai Chi on cognitive function, cerebral perfusion, and vascular function in postmenopausal women with mild cognitive impairment: an exploratory randomized controlled trial.Frontiers in aging neuroscience · 2026Article
- Ring-like (Donut-Shaped) Intracranial Aneurysms: A Warning Morphology of Mural Jet Flow and Pre-Rupture Instability.Diagnostics (Basel, Switzerland) · 2025Review
- Computational Fluid Dynamics Approaches for Analyzing Rupture and Growth of Intracranial Aneurysms: A Systematic Review.Biomedicines · 2025Review
- Management and Outcomes of Multiple Unruptured Cerebral Aneurysms: A Descriptive Cohort Analysis.Brain sciences · 2025Article
- The Declining Incidence Rate of Subarachnoid Hemorrhage in Four Local Japanese Regions Is Greater in Women than in Men: Japan Incidence of Subarachnoid Hemorrhage Study.Neurologia medico-chirurgica · 2025Article
- Risk factors for in-stent stenosis after flow-diverter implantation for intracranial aneurysm: a single center analysis of 161 consecutive patients.Acta neurochirurgica · 2025Article
- Differential Expression of LncRNA MIAT and Its Clinical Significance in Intracranial Aneurysms.Brain and behavior · 2025Article
- Two-Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation.Brain and behavior · 2025Article
- Understanding the stroke burden in Saudi Arabia: Trends from 1990 to 2019 and forecasting through time series analysis.Neurosciences (Riyadh, Saudi Arabia) · 2025Article
- Sex Differences in Intracranial Aneurysms: A Matched Cohort Study.Journal of personalized medicine · 2024Article
- Development of an Injectable, ECM-Derivative Embolic for the Treatment of Cerebral Saccular Aneurysms.Biomacromolecules · 2024Article
- Distribution of rupture sites and blebs on intracranial aneurysm walls suggests distinct rupture patterns in ACom and MCA aneurysms.International journal for numerical methods in biomedical engineering · 2024Article
- Gender-specific prognosis models reveal differences in subarachnoid hemorrhage patients between sexes.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracranial aneurysm (IA) is a frequent and generally asymptomatic cerebrovascular abnormality characterized as a localized dilation and wall thinning of intracranial arteries that preferentially arises at the arterial bifurcations of the circle of Willis. The devastating complication of IA is its rupture, which results in subarachnoid hemorrhage that can lead to severe disability and death. IA affects about 3% of the general population with an average age for detection of rupture around 50 years. IAs, whether ruptured or unruptured, are more common in women than in men by about 60% overall, and more especially after the menopause where the risk is double-compared to men. Although these data support a protective role of estrogen, differences in the location and number of IAs observed in women and men under the age of 50 suggest that other underlying mechanisms participate to the greater IA prevalence in women. The aim of this review is to provide a comprehensive overview of the current data from both clinical and basic research and a synthesis of the proposed mechanisms that may explain why women are more prone to develop IA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.