ArticleFrontiers in medicine2022
Evaluation of the Ocular Surface and Meibomian Gland in Obstructive Sleep Apnea Hypopnea Syndrome.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Comparison of ocular surface assessment outcomes between healthy controls and patients with obstructive sleep apnea-hypopnea syndrome: a meta-analysis of the literature.Frontiers in physiology · 2023Pooled it
- Association of obstructive sleep apnea and continuous positive airway pressure on risk of corneal ulceration and surgical interventions.International ophthalmology · 2026Article
- Application of large language models in clinical decision-making for dry eye disease.BMC medical informatics and decision making · 2026Article
- The Link between Obstructive Sleep Apnea and Dry Eye Disease: Pathophysiology and Current Updates.Ophthalmic research · 2026Review
- Article
- The effect of mask usage on dry eye symptoms and meibomian gland function in OSAS patients: an observational study.Sleep & breathing = Schlaf & Atmung · 2025Observational
- A multi-institutional cohort study on risk of sleep disorders in dry eyes patients using TriNetX.Scientific reports · 2025Article
- The Overlooked Floppy Eyelid Syndrome: From Diagnosis to Medical and Surgical Management.Diagnostics (Basel, Switzerland) · 2024Review
- Impact of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment on Dry Eye Disease: A Systematic Review and Meta-Analysis.Nature and science of sleep · 2024Review
- Alterations of ocular surface parameters in patients with obstructive sleep apnea syndrome.Frontiers in medicine · 2023Article
- Altered Intrinsic Regional Spontaneous Brain Activity in Patients With Severe Obesity and Meibomian Gland Dysfunction: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in human neuroscience · 2022Article
- Dry eye disease and tear film assessment through a novel non-invasive ocular surface analyzer: The OSA protocol.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess the ocular surface and meibomian gland (MG) of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and to explore the effects of surgery for OSAHS on the ocular surface and MG.
methodsBased on the apnea hypopnea index (AHI), 21 patients with mild OSAHS (Group A, 5/h ≤ AHI < 15/h), 20 patients with moderate OSAHS (Group B, 15/h ≤ AHI < 30/h), 62 patients with severe OSAHS (Group C, AHI ≥ 30/h) were examined. The ocular surface and MG were evaluated using Keratograph 5M. In addition, detailed Ophthalmic examination including visual acuity, refraction, slit-lamp examination of the anterior segment, corneal fluorescein staining (CFS), ocular surface disease index (OSDI) scoring, Schirmer I test (SIT) and serum lipid measurement was performed. For OSAHS patients with dry eye syndrome (DES) who underwent uvulopalatopharyngoplasty for improving AHI, the conditions of the ocular surface and MG were compared before surgery and 3 months after surgery. Only the data of the right eyes were analyzed.
resultsThere were no significantly different in the OSDI score, tear meniscus height (TMH), or loss ratio of the lower eyelid (LRLE) among these groups. The first non-invasive tear film breakup time (fNIBUT), average non-invasive tear film breakup time (avNIBUT), bulbar redness index (BRI), lipid layer grading (LLG), CFS, plugged orifices and distortion in MG, the loss ratio of upper eyelid (LRUE), and the incidence of DES, floppy eyelid syndrome (FES) and meibomian gland dysfunction (MGD) showed significant differences between Groups A and C (
conclusionPatients with severe OSAHS have poor stability of tear film and are prone to lipid-deficient dry eye as a result of the loss of meibomian gland. By improving the AHI, the ocular surface damage of OSAHS patients cannot be reversed in a short time.
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