ArticleFrontiers in medicine2022
Semiautomated and Automated Quantitative Analysis of Corneal Sub-Basal Nerves in Patients With DED With Ocular Pain Using IVCM.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- An Annotated Corneal Confocal Microscopy Dataset for Nerve Segmentation and Clinical Characterization.Scientific data · 2026Article
- Ocular surface oxidative stress, MMP-9, and corneal neuroimmune alterations in allergic conjunctivitis with dry eye: a cross-sectional study.Frontiers in medicine · 2026Article
- SuperCCM: An Open Source Python Toolkit for Automated Quantification of Corneal Nerve Fibers in Confocal Microscopy Images.Translational vision science & technology · 2025Article
- Methods for the evaluation of corneal nerve fibres in diabetes mellitus by in vivo confocal microscopy: a scoping review.BMJ open · 2025Article
- P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal.Translational vision science & technology · 2025Article
- Clinical Characterization of the Lacrimal Functional Unit in Patients with Chronic Ocular Pain Associated with Dry Eye Disease.Journal of clinical medicine · 2025Article
- Corneal epithelial dendritic cells associated with ocular pain in dry eye disease.International journal of ophthalmology · 2025Article
- Changes in bilateral tear film and corneal nerve stability in patients with unilateral neurotrophic keratitis.Frontiers in medicine · 2025Article
- Metabolomic analysis identifies alterations of amino acids in the tears and plasma of patients with dry eye disease with ocular pain.Frontiers in medicine · 2025Article
- Analysis of Clinical Characteristics and Neuropeptides in Patients with Dry Eye with and without Chronic Ocular Pain after FS-LASIK.Ophthalmology and therapy · 2024Article
- Comparison of Automated Versus Manual Analysis Programs for Quantification of Corneal Nerve Morphology in Patients With or Without Type 2 Diabetes Mellitus.Beyoglu eye journal · 2024Article
- Corneal nerve changes by anti-glaucoma medications examined byInternational journal of ophthalmology · 2024Article
- Clinical associations of corneal neuromas with ocular surface diseases.Neural regeneration research · 2024Review
- Article
- In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions.Communications biology · 2023Review
- Long-Term Clinical Outcome of Low-Temperature Plasma Ablation Treatment for Recurrent Corneal Erosions.Journal of clinical medicine · 2022Article
- Geometrical Features of Subbasal Corneal Whorl-like Nerve Patterns in Dry Eye Disease: An In Vivo Confocal Microscopy Study.Ophthalmology scienceArticle
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4 authors.
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Abstract
purposeInvestigate the correlation and agreement between the results of semiautomated and fully automated quantitative analysis of the corneal sub-basal nerve plexus (SNP) in patients with dry eye disease (DED) with ocular pain using
methodA total of 50 voluntary participants were enrolled in this study, i.e., 25 DED patients with ocular pain and 25 healthy controls. Each patient underwent an evaluation of ocular symptoms that utilized: the Ocular Surface Disease Index (OSDI), the Ocular Pain Assessment Survey (OPAS), the tear film breakup time (TBUT) test, the Schirmer test, corneal staining, and IVCM. Five SNP images of the cornea of each eye were selected and analyzed using a semiautomated analysis software (NeuronJ) and a fully automated method (ACCMetrics) to quantify corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), and corneal nerve fiber length (CNFL).
resultsThe intraclass correlation coefficient (ICC) of the CNFD (0.460 [0.382-0.532],
conclusionThere is a significant correlation between the measurements obtained via ACCMetrics and NeuronJ, especially for CNFL, which can be considered as the primary indicator in the diagnosis of DED with ocular pain. The SNP of the disease was significantly lower than that of healthy subjects.
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