Evidence map›Paper›PMID 35223920›Full record

ArticleFrontiers in medicine2022

Orthokeratology Lens Wear for 2 Years in Children Did Not Alter Tear Film Lipid Thickness by Non-Invasive Interferometry.

Haozhe Yu, Yifei Yuan, Wenyu Wu, Weizhen Zeng, Louis Tong, Yu Zhang, Yun Feng

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06023108 (A Single Center,Randomized,Controlled Trial Assessing the Effects of Spectacles or Orthokeratology on Dry Eye Parameters in Children and Adolescents.), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06023108 naunknown statusnot on this mapstarted 2023, after this paper: background citation

A Single Center,Randomized,Controlled Trial Assessing the Effects of Spectacles or Orthokeratology on Dry Eye Parameters in Children and Adolescents.

TypeinterventionalSponsorHe Eye HospitalRan2023 to 2024Enrolled300ConditionsDry Eye DiseaseArmsOrthokeratology, Spectacles
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haozhe YuDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yifei YuanDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Wenyu WuDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Weizhen ZengDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Louis TongSingapore Eye Research Institute, Singapore, Singapore.
Yu ZhangDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yun FengDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies suggest that overnight orthokeratology (OOK) may be detrimental to tear function. We aimed to investigate the effect of OOK on lipid layer thickness (LLT), blink pattern, and meibomian gland and elucidate the relationship of these variables.

methodsThirty-seven participants who wore OOK lenses every night for at least 2 years and twenty-four healthy non-contact lens wearers (controls) were enrolled in this retrospective study. LipiView interferometry, blink pattern analysis, the ocular surface status, and morphology and function of the meibomian gland were determined.

resultsThe OOK group and healthy controls had similar LLT, blink patterns, ocular surface status, and the function of the meibomian gland. OOK participants demonstrated higher meiboscore in the lower eyelids (

conclusionsWearing OOK for 2 or more years increased lower eyelid meibomian gland dropout but did not have a reduction of LLT.

Indexed as

dry eyelipid layer thicknessLipiViewmeibomian glandorthokeratology

Identifiers

PMID35223920
PMCPMC8866645

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Registered trials

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