Evidence map›Paper›PMID 35223915›Full record

ArticleFrontiers in medicine2022

Multimodal

Sergi Llambrich, Rubèn González, Julia Albaigès, Jens Wouters, Fopke Marain, Uwe Himmelreich, James Sharpe, Mara Dierssen, Willy Gsell, Neus Martínez-Abadías and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Sergi LlambrichBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Flanders, Belgium.
Rubèn GonzálezGrup de Recerca en Antropologia Biológica (GREAB), Department of Biologia Evolutiva, Ecologia i Ciències Ambientals (BEECA), Universitat de Barcelona, Barcelona, Spain.
Julia AlbaigèsCenter for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Jens WoutersBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Flanders, Belgium.
Fopke MarainBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Flanders, Belgium.
Uwe HimmelreichBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Flanders, Belgium.
James SharpeCenter for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Mara DierssenCenter for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.
Willy GsellBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Flanders, Belgium.
Neus Martínez-AbadíasGrup de Recerca en Antropologia Biológica (GREAB), Department of Biologia Evolutiva, Ecologia i Ciències Ambientals (BEECA), Universitat de Barcelona, Barcelona, Spain.
Greetje Vande VeldeBiomedical MRI, Department of Imaging and Pathology, KU Leuven, Flanders, Belgium.
KU Leuven · BECentre for Genomic Regulation · ESCentro de Investigación Biomédica en Red · ESEuropean Molecular Biology Laboratory · ESPompeu Fabra University · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain and skeletal systems are intimately integrated during development through common molecular pathways. This is evidenced by genetic disorders where brain and skull dysmorphologies are associated. However, the mechanisms underlying neural and skeletal interactions are poorly understood. Using the Ts65Dn mouse model of Down syndrome (DS) as a case example, we performed the first longitudinal assessment of brain, skull and neurobehavioral development to determine alterations in the coordinated morphogenesis of brain and skull. We optimized a multimodal protocol combining

Indexed as

brain and skull integrationdevelopmentdown syndromeGTE-EGCGμCT imagingμMRI

Identifiers

PMID35223915
PMCPMC8874331
OpenAlexW4211160696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.