ArticleFrontiers in medicine2022
Clinical and Multi-Mode Imaging Features of Eyes With Peripapillary Hyperreflective Ovoid Mass-Like Structures.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Peripapillary Hyperreflective Ovoid Mass-Like Structure as an Optic Disc Pseudo-Edema Case Report and Review.Case reports in ophthalmological medicine · 2026Article
- A Systematic Review of Optic Disc Drusen in the Modern Imaging Era: Structure-Function Correlates, Diagnostic Performance, and NAION Co-Occurrence.Diagnostics (Basel, Switzerland) · 2025Review
- The Observation of Peripapillary Hyperreflective Ovoid Mass-Like Structures in Adolescents by Swept-Source Optical Coherence Tomography Angiography.Translational vision science & technology · 2025Article
- Peripapillary choroidal vascularity of paediatric myopic eyes with peripapillary hyperreflective ovoid mass-like structures.Acta ophthalmologica · 2025Article
- Features of Peripapillary Hyperreflective Ovoid Mass-Like Structures in Nonarteritic Anterior Ischemic Optic Neuropathy Patients and Normal Controls.Translational vision science & technology · 2024Article
- Multimodal imaging of optic nerve head abnormalities in high myopia.Frontiers in neurology · 2024Review
- Spontaneous Focal Hemorrhage of Optic Disc in Peripapillary Hyperreflective Ovoid Mass-Like Structures.International medical case reports journal · 2024Article
- Peripapillary hyperreflective ovoid mass-like structures: multimodal imaging and associated diseases.Frontiers in neurology · 2024Review
- Peripapillary hyperreflective ovoid mass-like structures: Multimodal imaging-A review.Clinical & experimental ophthalmology · 2023Review
- Peripapillary hyper-reflective ovoid mass-like structures (PHOMS): clinical significance, associations, and prognostic implications in ophthalmic conditions.Frontiers in neurology · 2023Review
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Authors and funding
9 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo observe and analyze the clinical and multi-mode imaging features of eyes with PHOMS, and to introduce two cases of PHOMS which underwent multi-mode imaging.
methodsRetrospective clinical observational study. A total of 26 patients (37 eyes) with hyperreflective structures surrounded by hyporeflective edges around the optic discs who were examined and diagnosed at Shandong Eye Hospital between January 2019 and June 2021 were included in the study. Among these patients, 12 were male and 14 were female. Fifteen were monocular. The average age was 39 years. All patients underwent the following examinations: Best-corrected visual acuity (BCVA), intraocular pressure examinations, slit-lamp anterior segment examinations, indirect ophthalmoscopy, visual field examinations, fundus color photography, fundus autofluorescence (FAF), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA). Some of the patients were examined with fundus fluorescein angiography (FFA). Clinical data and imaging characteristics from the OCT, OCTA, and FFA were analyzed retrospectively.
resultsWe found the hyperreflective structures surrounded by hyporeflective edges around the optic discs in 37 eyes. EDI-OCT results revealed hyperreflective structures surrounded by hyporeflective edges around the optic discs in all eyes. Typical hyperreflexia lesions occurred around the optic disc, located subretinally and above Bruch's membrane. OCTA revealed that the highly reflective perioptic material also had vascular structures.
conclusionEDI-OCT of PHOMS showed hyperreflective structures surrounded by hyporeflective edges around all of the optic discs. Infra-red photography showed temporal hyperreflexia. These characteristics can be seen in a variety of diseases and may be a relatively common feature revealed by EDI-OCT scanning. These characteristics may also be seen in elderly patients as well as children. PHOMS may be found in optic disc drusen (ODD), tilted disc syndrome (TDS), optic neuritis, ischemic optic neuropathy, and in white dot syndromes. Few patients may be developed into macular neovascularization (MNV). In order to improve the accuracy and robustness of the conclusions and provide better clinical guidance, we need to conduct more comprehensive research in the subsequent clinical work.
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