Evidence map›Paper›PMID 35223889›Full record

ArticleFrontiers in medicine2022

Complementing Tissue Testing With Plasma Mutation Profiling Improves Therapeutic Decision-Making for Patients With Lung Cancer.

Yukti Choudhury, Min-Han Tan, Jun Li Shi, Augustine Tee, Kao Chin Ngeow, Jonathan Poh, Ruth Rosalyn Goh, Jamie Mong

Open access · goldAbstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Yukti ChoudhuryLucence Diagnostics Pte. Ltd., Singapore, Singapore.
Min-Han TanLucence Health Inc, Palo Alto, CA, United States.
Jun Li ShiInstitute of Bioengineering and Nanotechnology, Singapore, Singapore.
Augustine TeeDepartment of Respiratory and Critical Care Medicine, Changi General Hospital, Singapore, Singapore.
Kao Chin NgeowLucence Diagnostics Pte. Ltd., Singapore, Singapore.
Jonathan PohLucence Diagnostics Pte. Ltd., Singapore, Singapore.
Ruth Rosalyn GohLucence Diagnostics Pte. Ltd., Singapore, Singapore.
Jamie MongInstitute of Bioengineering and Bioimaging, Singapore, Singapore.
Changi General Hospital · SGImperial College London · GBInstitute of Bioengineering and Nanotechnology · SGSingapore Bioimaging Consortium · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTissue biopsy is an integral part of the diagnostic approach to lung cancer. It is however invasive and limited by heterogeneity. Liquid biopsies may complement tissue testing by providing additional molecular information and may be particularly helpful in patients from whom obtaining sufficient tissue for genomic profiling is challenging.

methodsPatients with suspected lung cancer (

resultsFor confirmed NSCLC cases (

conclusionsIn the first-line setting, plasma NGS was highly concordant with tissue

Indexed as

amplicon-based NGSliquid biopsy and circulating tumor DNAnext generation sequencingNGS panel testingnon-small cell lung cancer (NSCLC)plasma-firsttumor heterogeneity

Identifiers

PMID35223889
PMCPMC8873935
OpenAlexW4211163929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.