Evidence map›Paper›PMID 35223832›Full record

ArticleFrontiers in cell and developmental biology2022

Exosomes Mediate APP Dysregulation

Lu Ding, Xiaoyu Yang, Xiaohuan Xia, Yunxia Li, Yi Wang, Chunhong Li, Yiyan Sun, Ge Gao, Shu Zhao, Shiyang Sheng and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. MicroRNA cargo in neuron-derived vesicles as peripheral biomarkers of brain insulin dysregulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
  8. Article
  9. Article
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  13. Cell-cell communication: new insights and clinical implications.Signal transduction and targeted therapy · 2024
    Review
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  17. Review
  18. Article
  19. Frontiers in cell and developmental biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lu DingDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Xiaoyu YangDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Xiaohuan XiaDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Yunxia LiDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Yi WangCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Chunhong LiCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Yiyan SunDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Ge GaoCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Shu ZhaoCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Shiyang ShengCenter for Translational Neurodegeneration and Regenerative Therapy, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Jianhui LiuDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Jialin C ZhengDepartment of Anesthesiology, Tongji Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

APP misexpression plays a crucial role in triggering a complex pathological cascade, leading to Alzheimer's disease (AD). But how the expression of APP is regulated in pathological conditions remains poorly understood. In this study, we found that the exosomes isolated from AD mouse brain promoted APP expression in neuronal N2a cells. Moreover, exosomes derived from N2a cells with ectopic expression of APP (APP-EXO) also induced APP dysregulation in normal N2a cells. Surprisingly, the effects of APP-EXO on APP expression in recipient cells were not mediated by the direct transferring of

Indexed as

Alzheimer’s diseaseAPPbrainexosomeextracellular vesiclemicroRNAmiR-185-5pserum

Identifiers

PMID35223832
PMCPMC8873530

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.