Evidence map›Paper›PMID 35223781›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Icariin-Loaded Hydrogel Regulates Bone Marrow Mesenchymal Stem Cell Chondrogenic Differentiation and Promotes Cartilage Repair in Osteoarthritis.

Yuefeng Zhu, Le Ye, Xiaoxi Cai, Zuhao Li, Yongqian Fan, Fengjian Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yuefeng ZhuDepartment of Orthopedics, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Le YeDepartment of Pain, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Xiaoxi CaiDepartment of Orthopedics, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Zuhao LiDepartment of Pain, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yongqian FanDepartment of Orthopedics, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Fengjian YangDepartment of Orthopedics, Huadong Hospital Affiliated to Fudan University, Shanghai, China.
Fudan University · CNHuadong Hospital · CNRenji Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intra-articular injection of mesenchymal stem cells is a potential therapeutic strategy for cartilage protection and symptom relief for osteoarthritis (OA). However, controlling chondrogenesis of the implanted cells in the articular cavity remains a challenge. In this study, hydrogels containing different concentrations of icariin were prepared by

Indexed as

BMSCscartilage repairhydrogelicariinosteoarthritispain relief

Identifiers

PMID35223781
PMCPMC8864219
OpenAlexW4210868600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.