ArticleCanadian journal of gastroenterology & hepatology2022
Risk Factors of Young-Onset Colorectal Cancer: Analysis of a Large Population-Based Registry.
Article in Canadian journal of gastroenterology & hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Early-onset colorectal cancer is associated with metabolic disorders: a systematic review and meta-analysis.European journal of epidemiology · 2026Pooled it
- Incidence and risk factors for colorectal cancer in Africa: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- Closing the Diagnostic Gap in Early-Onset Colorectal Cancer: Red-Flag Symptoms, Screening, and Inherited Risk.Cancers · 2026Review
- Review
- Risk Factors in Sporadic Early-Onset Colorectal Cancer, Current Evidence and Emerging Insights: A Systematic Review.Cancers · 2026Review
- Exploring the role of marital status on survival and stage at diagnosis in early-onset colorectal cancer by race/ethnicity.Scientific reports · 2026Article
- Factors associated with the incidence of young-onset colorectal cancer: A cross-sectional study.Narra J · 2025Article
- The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms.Cell biochemistry and biophysics · 2025Review
- Article
- Sex and age-related differences in one-, three-, and five-year survival for early-onset colorectal cancer in Georgia.American journal of cancer research · 2025Article
- Sex difference in alcohol consumption associated with colorectal cancer risk in Quzhou, China: A nested case-control study.Preventive medicine reports · 2024Article
- Stable Dietary Ora-Curcumin Formulation Protects from Experimental Colitis and Colorectal Cancer.Cells · 2024Article
- The Clinicopathological Characteristics of Young-Onset Versus Adult-Onset Colorectal Cancer: A Tertiary Hospital-Based Study.The Malaysian journal of medical sciences : MJMS · 2024Article
- Obesity and early-onset colorectal cancer risk: emerging clinical evidence and biological mechanisms.Frontiers in oncology · 2024Review
- Prediction of liver and lung metastases in patients with early-onset colorectal cancer by nomograms based on heterogeneous and homogenous risk factors.Cancer medicine · 2023Article
- Risk factors for the postoperative recurrence of ulcerative colitis-associated colorectal cancer.International journal of colorectal disease · 2023Article
- Early-onset colorectal cancer: A review of current knowledge.World journal of gastroenterology · 2023Review
- Genetic Variants of HOTAIR Associated with Colorectal Cancer: A Case-Control Study in the Saudi Population.Genes · 2023Article
- Autoimmune and Metabolic Diseases and the Risk of Early-Onset Colorectal Cancer, a Nationwide Nested Case-Control Study.Cancers · 2023Article
- Risk factors for early-onset colorectal cancer: systematic review and meta-analysis.Frontiers in oncology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs the third most common type of cancer in the United States, colorectal cancer (CRC) was previously thought to be rare in young populations. Despite a decrease in the overall incidence of CRC, the rate of new cases under 50 years old has been continuously increasing.
aimThe purpose of our study was to analyze risk factors of young-onset CRC.
methodsCommercially available software platform, Explorys, was used to extract data from a collective healthcare database electronically.
resultsIn this database, 13,800 young adults (age 20-50) were diagnosed with primary colorectal malignancy. Compared to subjects with a previous family history of CRC who had an odds ratio of 17.78, those diagnosed with primary malignant neoplasm of breast and inflammatory bowel disease (ulcerative colitis and Crohn's) had odds ratios of 16.94, 4.4, and 3.7 for young-onset CRC, respectively. Patients with a history of alcohol abuse, smoking, obesity, diabetes mellitus, and hyperlipidemia had higher chances of developing young-onset CRC. In addition, the odds of CRC were lower in Hispanic ethnicity in comparison to Caucasians (OR: 0.54), with no statically significant differences between Caucasian, African American, and Asian populations.
conclusionCurrently, this is an expansive study investigating the risk factors for early-onset CRC. The analysis showed factors such as family and individual history of IBD to have high association with early onset. Notably, an individual history of breast malignancy was strongly associated with early-onset CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.