ArticleClinical and experimental vaccine research2022
Expression of full and fragment-B of diphtheria toxin genes in
Article in Clinical and experimental vaccine research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Optimization and scalable production of Corynebacterium diphtheriae toxin using an animal component free medium: a pathway towards safer vaccine development.Archives of microbiology · 2025Article
- Recent development of oral vaccines (Review).Experimental and therapeutic medicine · 2024Review
- Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes.Toxins · 2023Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn the present study, whole diphtheria toxin (dt) and fragment B (dtb) genes from MATERIALS AND
methodsThe dt and dtb genes were isolated from bacterial strain ATCC (American Type Culture Collection) no. 13812. Plasmid pET29a+ was extracted by DNA-spin TM plasmid purification kit where genes were inserted using BamHI and HindIII-HF. Cloned pET29a+dt and pET29a+dtb plasmids were transformed into
resultsThe genetic transformation of
conclusionThis study concluded with success in preparing genetically modified two strains for the production of a diphtheria vaccine, and to reach ideal production conditions to achieve the highest productivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.