Evidence map›Paper›PMID 35223484›Full record

ArticleFrontiers in oncology2022

Enhancing Performance of Breast Ultrasound in Opportunistic Screening Women by a Deep Learning-Based System: A Multicenter Prospective Study.

Chenyang Zhao, Mengsu Xiao, Li Ma, Xinhua Ye, Jing Deng, Ligang Cui, Fajin Guo, Min Wu, Baoming Luo, Qin Chen and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

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  6. Whole-lesion-aware network based on freehand ultrasound video for breast cancer assessment: a prospective multicenter study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 1 country.

Chenyang ZhaoDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Mengsu XiaoDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li MaDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xinhua YeDepartment of Ultrasound, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Jing DengDepartment of Ultrasound, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Ligang CuiDepartment of Ultrasound, Peking University Third Hospital, Beijing, China.
Fajin GuoDepartment of Ultrasound, Beijing Hospital, Beijing, China.
Min WuDepartment of Ultrasound, Nanjing Drum Tower Hospital, Nanjing, China.
Baoming LuoDepartment of Ultrasound, Sun Yat-sen Memorial Hospital, Guangzhou, China.
Qin ChenDepartment of Ultrasound, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Wu ChenDepartment of Ultrasound, First Hospital of Shanxi Medical University, Taiyuan, China.
Jun GuoDepartment of Ultrasound, Aero Space Central Hospital, Beijing, China.
Qian LiDepartment of Ultrasound, Henan Provincial Cancer Hospital, Zhengzhou, China.
Qing ZhangDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jianchu LiDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yuxin JiangDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Qingli ZhuDepartment of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNPeking Union Medical College Hospital · CNNanjing Medical University · CNAerospace Center Hospital · CNBeijing Hospital · CNHenan Cancer Hospital · CNNanjing Drum Tower Hospital · CNPeking University · CNShanxi Medical University · CNSun Yat-sen University · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo validate the feasibility of S-Detect, an ultrasound computer-aided diagnosis (CAD) system using deep learning, in enhancing the diagnostic performance of breast ultrasound (US) for patients with opportunistic screening-detected breast lesions.

methodsNine medical centers throughout China participated in this prospective study. Asymptomatic patients with US-detected breast masses were enrolled and received conventional US, S-Detect, and strain elastography subsequently. The final pathological results are referred to as the gold standard for classifying breast mass. The diagnostic performances of the three methods and the combination of S-Detect and elastography were evaluated and compared, including sensitivity, specificity, and area under the receiver operating characteristics (AUC) curve. We also compared the diagnostic performances of S-Detect among different study sites.

resultsA total of 757 patients were enrolled, including 460 benign and 297 malignant cases. S-Detect exhibited significantly higher AUC and specificity than conventional US (AUC, S-Detect 0.83 [0.80-0.85] vs. US 0.74 [0.70-0.77],

conclusionsCompared with the conventional US, S-Detect presented higher overall accuracy and specificity. After S-Detect and strain elastography were combined, the performance could be further enhanced. The performances of S-Detect also varied among different centers.

Indexed as

breast cancercomputer-aided diagnosisdeep learningelastographyultrasound

Identifiers

PMID35223484
PMCPMC8867611
OpenAlexW4211231212

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.