ReviewBioMedicine2021
Inflammation, oxidative stress, insulin resistance, and hypertension as mediators for adverse effects of obesity on the brain: A review.
Review in BioMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- Sleep Quality, Metabolic Function, Physical Activity, and Neurocognition Among Individuals with Resistant Hypertension.Journal of Alzheimer's disease : JAD · 2023Trial
- Bariatric surgery and risk of dementia and Parkinson's disease in patients with obesity.International journal of obesity (2005) · 2026Article
- Wilson's Disease Coexisting with Narcolepsy Type 1: Evidence for a Multifactorial Cause of Excessive Daytime Sleepiness from a Case Report.Neurology and therapy · 2026Article
- Stress biology and metabolic ageing in older adults during prolonged crises: Ukraine as an example.Biogerontology · 2026Review
- The role of metabolic health in neurostructural and cognitive alterations in bipolar disorders.Psychological medicine · 2026Article
- Interpretable Machine Learning for Predicting Metabolic Syndrome-Kidney Stone Disease Comorbidity: The Role of Dietary Micronutrients.Food science & nutrition · 2026Article
- Neuroprotective effects of hydrogen sulfide on BDNF, IGF-1, and oxidative stress in the hippocampus of high-fat diet rats.IBRO neuroscience reports · 2026Article
- The association of the composite dietary antioxidant index with the risk of cardiometabolic disorders: findings from the Tehran Lipid and Glucose Study.Journal of health, population, and nutrition · 2026Article
- Programmed Cell Death Ligand 1 Is Essential for Electroacupuncture-Mediated Analgesia in the Cerebellum of Fibromyalgia Mice.Biomedicines · 2026Article
- Unraveling the Cross-Tissue Neuroimmune-Vascular Genetic Architecture of Migraine Using Integrated Multi-Omics, Single-Cell, and Spatial Transcriptomics: Prioritizing T-Cell Regulatory Networks and Peripheral Targets.International journal of molecular sciences · 2026Article
- Serum S100β and neuron-specific enolase correlate with obesity parameters in Mexican children.International journal of obesity (2005) · 2026Article
- Intervention effects of high-intensity interval exercise and moderate-intensity continuous exercise on executive functions in obese adolescents with low socioeconomic status.Frontiers in psychology · 2026Article
- Pharmacological modulation of the PI3K/AKT/GSK3β axis: a new frontier in Alzheimer's disease treatment.Inflammopharmacology · 2026Review
- The effects of 12-weeks resveratrol supplementation on cognition, gastrointestinal microbiota, and systemic inflammation, in an overweight and obese human population: a randomized, double-blind, placebo controlled, parallel groups trial.Frontiers in nutrition · 2026Article
- Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions.Annals of medicine · 2025Review
- Relation of glucose variability on mortality from any cause and cardiovascular diseases in individuals with type 2 diabetes: mediation analysis of echocardiographic parameters.BMC cardiovascular disorders · 2025Article
- Chemogenetic Modulation of Electroacupuncture Analgesia in a Mouse Intermittent Cold Stress-Induced Fibromyalgia Model by Activating Cerebellum Cannabinoid Receptor 1 Expression and Signaling.Life (Basel, Switzerland) · 2025Article
- Article
- Relationship between oxygen radical absorbance capacity (ORAC) index, body composition and blood biochemical markers in overweight/obese compared to normal weight subjects: a cross-sectional study.Journal of health, population, and nutrition · 2025Article
- The Effects of Abdominal Draw-In Maneuvers Combined with Blood Flow Restriction on the Transverse Abdominis in University Students with Sedentary Lifestyles.Life (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nowadays, the incidence of obesity is a global challenge and it is estimated that the total number of overweight and obese adults will increase up to 1.35 billion by 2030. Evidence obtained from clinical and experimental studies shows that obesity may be associated with cognitive performance and executive function impairments. Considering various evidence for the poor episodic memory tasks and verbal learning as well as the destruction of cortical gray matter in the obese individuals, here, we collected some causal pathways for contribution of inflammation, oxidative stress, insulin resistance, and hypertension in the development of brain disorders in obesity. The present study focuses on the providing an overview of the some negative effects of obesity on the brain. Different evidence mentioned in this review has thrown light on the obesity-associated complications which may predispose obese people to brain damage, dementia, and Alzheimer's disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.