ArticleBioMedicine2021
The influence of TAS2R38 bitter taste gene polymorphisms on obesity risk in three racially diverse groups.
Article in BioMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05528874 (Glycemic Index Analysis of Functional Bakery Products on a Group of Healthy Volunteers, a NUTRACORE Study), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Glycemic Index Analysis of Functional Bakery Products on a Group of Healthy Volunteers, a NUTRACORE Study
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Association between Bitter Taste Sensitivity and Weight Status in Adults: A Systematic Review and Meta-Analysis.Nutrition reviews · 2026Pooled it
- Regulation of the murine preadipocytes differentiation by bitter taste receptor Tas2r108 and Tas2r126.Molecular and cellular biochemistry · 2026Article
- Clinical Presentation of Chronic Abacterial Prostatitis Shows No Association with TAS2R38 Taster Status.Urologia internationalis · 2026Article
- Genetic Variants Increasing TAS2R38 Bitter Taste Receptor Sensitivity Are Associated With Lower Postprandial Glycemia.Diabetes · 2025Article
- Extra-oral expression of bitter taste receptors in pigs and their correlation with hepatic cytochrome P450 enzymes.Cell and tissue research · 2025Article
- Associations of TAS1R2 and TAS2R38 Genetic Variants with Sugar-Sweetened Beverage Intake and Obesity Risk in Kuwaiti Adolescents: A Cross-Sectional Study.Children (Basel, Switzerland) · 2025Article
- Bitter Taste Receptors in Bacterial Infections and Innate Immunity.Immunity, inflammation and disease · 2025Review
- Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38.European journal of nutrition · 2025Article
- Investigation of CBX4 Polymorphisms and Their Association with Clinicopathological Features in Asian Patients with Oral Squamous Cell Carcinoma.Journal of Cancer · 2025Article
- Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025Review
- Association between Variants of the TRPV1 Gene and Body Composition in Sub-Saharan Africans.Genes · 2024Article
- Neophobia, sensory experience and child's schemata contribute to food choices.Eating and weight disorders : EWD · 2024Review
- Profiling bitter taste receptors (TAS2R) along the gastrointestinal tract and their influence on enterohormone secretion. Gender- and age-related effects in the colon.Frontiers in endocrinology · 2024Article
- Analysis of MUC6 polymorphisms on the clinicopathologic characteristics of Asian patients with oral squamous cell carcinoma.Journal of cellular and molecular medicine · 2023Article
- TT Genotype ofNutrients · 2023Article
- Article
- Clinical Associations of Bitter Taste Perception and Bitter Taste Receptor Variants and the Potential for Personalized Healthcare.Pharmacogenomics and personalized medicine · 2023Article
- Taste 2 Receptor Is Involved in Differentiation of 3T3-L1 Preadipocytes.International journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBitter taste perception affects food preference, eating behavior, and nutrient intake. The purpose of this study was to investigate the contribution of bitter taste gene polymorphisms to body fatness as measured by percentage of body fat.
methodThree common single nucleotide polymorphisms (SNPs) of the TAS2R38 gene which result in amino acid changes in the protein (A49P, V262A, and I296V), were studied in three racially diverse groups: European Americans n = 313, African Americans n = 109, and Asians n = 234.
resultsThe allele frequencies of the three SNPs were similar to previous studies. The rare haplotypes, AAI and AAV, were found in high prevalence in the African American subgroup (22.94%) and European American subgroup (6.07%). The PROP non taster; AVI/AVI diplotype was associated with a higher risk of obesity in European American and Asian but not African American subjects after age adjustment.
conclusionsTAS2R38 polymorphisms could be associated with obesity development. In addition to taste perception, nutrient sensing and energy metabolism should be studied in relation to bitter taste receptors to confirm the association between genetic polymorphisms and body fatness. Genetic polymorphisms, race, gender, and environmental factors such as dietary patterns could all contribute to body fat.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.