ArticleBioMedicine2021
Konjac glucomannan polysaccharide and inulin oligosaccharide ameliorate dextran sodium sulfate-induced colitis and alterations in fecal microbiota and short-chain fatty acids in C57BL/6J mice.
Article in BioMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Gastrointestinal Tract Remodeling by Dietary Polysaccharides Mechanistic Insights in Colitis-A Review.Foods (Basel, Switzerland) · 2026Review
- Epidemiology of diagnosed inflammatory bowel disease in Taiwan population from 2011 to 2021: a population-based study.BMC gastroenterology · 2026Article
- Synephrine potentiates lidocaine-induced cutaneous analgesia via α-adrenergic receptors in male rats.Physiological reports · 2026Article
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- Synergistic Effects of Plant Polysaccharides and Probiotics: A Novel Dietary Approach for Parkinson's Disease Intervention.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Ultrasound-Assisted Deep Eutectic Solvent-Based Extraction of Polysaccharides from Okra: Optimization by Response Surface Methodology and Artificial Neural Network Modeling.Ultrasonics sonochemistry · 2026Article
- Review
- Review
- Unraveling autophagy-related pathogenesis in active ulcerative colitis: A bioinformatics approach.World journal of clinical cases · 2024Article
- Prebiotic selection influencing inflammatory bowel disease treatment outcomes: a review of the preclinical and clinical evidence.eGastroenterology · 2024Review
- Refined fiber inulin promotes inflammation-associated colon tumorigenesis by modulating microbial succinate production.Cancer reports (Hoboken, N.J.) · 2023Article
- The oligosaccharides of Xiasangju alleviates dextran sulfate sodium-induced colitis in mice by inhibiting inflammation.PloS one · 2023Article
- Combined inulin and glucomannan modulate colonic cytokine balance and mucosal barrier function in a western diet-induced colonic inflammation mouse model.Journal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKonjac glucomannan polysaccharide (KGM), inulin oligosaccharide (inulin) and their mixture has been shown to modulate the gut-associated lymphoid tissue immunity.
aimsThe present study was mainly to determine effects of a low-level (2% w/w) KGM and inulin and their combination on dextran sodium sulfate (DSS)-induced colitis. We also determine the potential mechanisms mediating these effects of dietary fibers.
methodsC57BL/6J mice (6 weeks of age, eight per group) were randomly assigned to consume one of the following diets: control (DSS group) or control diet supplemented with 2% (w/w) of KGM (KGM group), 2% (w/w) of inulin oligosaccharide (inulin group) or KGM+Inulin (1%, w/w each (K+I group)) for 29 days, combined with the DSS drinking water (2% w/v) treatment on days 21-26. Another group served as vehicle was fed the control diet and given regular drinking water throughout the study. Fresh feces were collected on days 26-29. Mice were killed on day 30 after fasting. Segments of distal colon were processed for histological procedure. The remaining colonic tissues were processed to determine the colonic gene expressions of cytokines, tight junction proteins and antioxidant enzymes.
resultsThe present study indicated that DSS resulted in colonic dysplasia, severe leukocyte infiltration and enhanced gene expressions of pro-inflammatory cytokines. All fiber treatments ameliorated these indices of colitis. DSS treatment reduced the colonic gene expressions of tight junction proteins and antioxidant enzymes, which were ameliorated or normalized with fiber supplementation. In addition, all fiber treatments prevented the DSS-induced alterations in the fecal microbiota and short-chain acid levels.
conclusionSupplementation of low-level, 2% (w/w), of KGM polysaccharide, inulin oligosaccharide and K + I reduced the DSS-induced colitis and mucosal barrier dysfunction, which was likely to be mediated by the prebiotic effects.
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