Evidence map›Paper›PMID 35223381›Full record

ReviewNanotheranostics2022

Molecular Immune Targeted Imaging of Tumor Microenvironment.

Taha Rakhshandehroo, Bryan Ronain Smith, Hannah J Glockner, Mohammad Rashidian, Neeta Pandit-Taskar

Abstract readReview
In one paragraph

Review in Nanotheranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Radiopharmaceutical application of TRK-950, an anti-CAPRIN-1 therapeutic antibody.Journal of cancer research and clinical oncology · 2025
    Article
  3. Review
  4. Ultra-low dose immunoPET usingFrontiers in medicine · 2025
    Article
  5. [Immunotherapy advances · 2025
    Article
  6. Article
  7. Review
  8. Acta pharmacologica Sinica · 2024
    Article
  9. Review
  10. Review
  11. Reporter Genes for Brain Imaging Using MRI, SPECT and PET.International journal of molecular sciences · 2022
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Taha RakhshandehrooDepartment of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Bryan Ronain SmithDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
Hannah J GlocknerDepartment of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Mohammad RashidianDepartment of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Neeta Pandit-TaskarDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY and Weill Cornell Medical College, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Novel targeted therapies are rapidly emerging for the treatment of cancer. With the advent of new immune targeting agents, understanding the changes in the tumor microenvironment (TME) is critical. Given the complexity and several cellular mechanisms and factors that play a role in the TME, novel imaging methods to assess and evaluate the dynamic changes in the TME during treatment are needed. Several techniques are being developed for imaging TME including optical, fluorescence and photoacoustic methods. Positron emission tomography (PET) imaging can be used to track the dynamics of different molecular targets in the TME in live animals and in humans. Several novel PET imaging probes including radiolabeled antibodies, antibody fragments, and small molecules have been developed with many more that are under development preclinically and in early human studies. This review is a brief overview of some of the PET agents that are either in the preclinical developmental phase or undergoing early clinical studies.

Indexed as

NeoplasmsTumor MicroenvironmentAnimalsPositron-Emission TomographyBiomarkercheckpoint inhibitorsFDGPD-1PD-L1radiolabeled antibody

Identifiers

PMID35223381
PMCPMC8864253

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.