Evidence map›Paper›PMID 35223380›Full record

ArticleNanotheranostics2022

Intracellular vesicle entrapment of nanobubble ultrasound contrast agents targeted to PSMA promotes prolonged enhancement and stability

Reshani H Perera, Eric Abenojar, Pinunta Nittayacharn, Xinning Wang, Gopal Ramamurthy, Pubudu Peiris, Ilya Bederman, James P Basilion, Agata A Exner

Open access · goldAbstract read
In one paragraph

Article in Nanotheranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecular Ultrasound Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Nanobubble Contrast Enhanced Ultrasound Imaging: A Review.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
  15. Life at the interface: Engineering bio-nanomaterials through interfacial molecular self-assembly.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Reshani H PereraDepartment of Radiology Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Eric AbenojarDepartment of Radiology Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Pinunta NittayacharnDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Xinning WangDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Gopal RamamurthyDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Pubudu PeirisDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Ilya BedermanDepartment of Genetics and Genome Sciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
James P BasilionDepartment of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Agata A ExnerDepartment of Radiology Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.
Case Western Reserve University · US

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Amar Desai · 1987 to 2026
$142.3M
Improved Detection of Prostate Cancer with Nanoparticle-based Ultrasound Contrast Agents Targeted to PSMAR01EB025741 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI James Peter Basilion, Agata A Exner · 2018 to 2026
$4.1M
Drug-Loaded Nanobubbles for Ultrasound Enhanced Delivery to Colon Cancer Liver MetastasisR01EB028144 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI EXNER, AGATA A · 2019 to 2023
$2.3M
High resolution ultrasound for small animal imagingS10OD021635 · OD · CASE WESTERN RESERVE UNIVERSITY · PI STELZER, JULIAN · 2016 to 2016
$478k
NCI NIH HHS P30 CA043703NIBIB NIH HHS R01 EB025741NIBIB NIH HHS R01 EB028144NIH HHS S10 OD021635
6 · The paper itself

Abstract

Gas-core nanoscale bubbles (or nanobubbles) have gained significant recent attention as promising contrast agents for cancer molecular imaging using medical ultrasound. Previous work has shown that active targeting of nanobubbles to tumor biomarkers such as the prostate-specific membrane antigen (PSMA) significantly prolongs ultrasound signal enhancement, which is a critical feature for successful tumor diagnosis. However, the specific mechanism behind this effect is not well understood, and has not been previously studied in detail. Thus, in the current work, we investigated the process of PMSA- targeted nanobubble transport in tumors across different scales from

Indexed as

Contrast MediaProstatic NeoplasmsAnimalsCell Line, TumorHumansMaleMiceMice, NudeUltrasonographyContrast Mediacellular internalizationnanobubble ultrasound contrast agentsprostate cancerprostate-specific membrane antigen (PSMA)ultrasound molecular imaging

Identifiers

PMID35223380
PMCPMC8864252
OpenAlexW4220771639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.