Evidence map›Paper›PMID 35222920›Full record

ArticleChemical science2022

Enabling chemical protein (semi)synthesis

Jiamei Liu, Tongyao Wei, Yi Tan, Heng Liu, Xuechen Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Review
  3. Uncovering a Latent Bioactive Interleukin-6 Glycoform.Angewandte Chemie (International ed. in English) · 2024
    Article
  4. Review
  5. Article
  6. Total synthesis of interleukin-2Chemical science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiamei LiuDepartment of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong Hong Kong xuechenl@hku.hk.
Tongyao WeiDepartment of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong Hong Kong xuechenl@hku.hk.
Yi TanDepartment of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong Hong Kong xuechenl@hku.hk.
Heng LiuDepartment of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong Hong Kong xuechenl@hku.hk.
Xuechen LiDepartment of Chemistry, State Key Lab of Synthetic Chemistry, The University of Hong Kong Hong Kong xuechenl@hku.hk.ORCID https://orcid.org/0000-0001-5465-7727
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemical synthesis of proteins with poor solubility presents a challenging task. The existing solubilizing tag strategies are not suitable for the expressed protein segment. To address this issue, we report herein that solubilizing tags could be introduced at the side chain of the peptide and C-terminal peptide salicylaldehyde esters

Identifiers

PMID35222920
PMCPMC8809390
OpenAlexW4200060846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.