Evidence map›Paper›PMID 35222803›Full record

ArticleOxidative medicine and cellular longevity2022

Protection of Human Lens Epithelial Cells from Oxidative Stress Damage and Cell Apoptosis by KGF-2 through the Akt/Nrf2/HO-1 Pathway.

Shuyu Liu, Zi Jin, Ruyue Xia, Zhuoni Zheng, Yi Zha, Qiang Wang, Xinbei Wan, Hui Yang, Jianqiu Cai

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Oxidative Stress in Genetic Cataract Formation.Antioxidants (Basel, Switzerland) · 2024
    Review
  11. Review
  12. Article
  13. [Differential expression of circRNAs in anterior lens capsules of high myopic patients with cataract].Nan fang yi ke da xue xue bao = Journal of Southern Medical University
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shuyu LiuDepartment of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0001-5860-4462
Zi JinSchool of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0001-5432-7170
Ruyue XiaDepartment of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0003-2510-2233
Zhuoni ZhengDepartment of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0001-7431-0245
Yi ZhaDepartment of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0002-6955-0049
Qiang WangDepartment of Ophthalmology, Ruian People's Hospital, Wenzhou 325000, China.ORCID https://orcid.org/0000-0003-2041-2187
Xinbei WanDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada H3A 1G1.ORCID https://orcid.org/0000-0002-9426-7843
Hui YangDepartment of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0001-9583-9076
Jianqiu CaiDepartment of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.ORCID https://orcid.org/0000-0003-3086-2050
Wenzhou Medical University · CNMcGill University Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress exerts a significant influence on the pathogenesis of various cataracts by inducing degradation and aggregation of lens proteins and apoptosis of lens epithelial cells. Keratinocyte growth factor-2 (KGF-2) exerts a favorable cytoprotective effect against oxidative stress

Indexed as

AnimalsApoptosisCataractCell LineCell SurvivalEpithelial CellsFibroblast Growth Factor 10Heme Oxygenase-1HumansHydrogen PeroxideLens, CrystallineNF-E2-Related Factor 2Oxidative StressPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktRatsFibroblast Growth Factor 10Heme Oxygenase-1HMOX1 protein, humanHydrogen PeroxideNFE2L2 protein, humanNF-E2-Related Factor 2Phosphatidylinositol 3-KinaseProto-Oncogene Proteins c-akt

Identifiers

PMID35222803
PMCPMC8872674
OpenAlexW4213388457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.