Evidence map›Paper›PMID 35222750›Full record

ArticleJournal of arrhythmia2022

Age-dependency of EHRA improvement based on quality of life at diagnosis of atrial fibrillation.

Luc J H J Theunissen, Henricus-Paul Cremers, Dennis van Veghel, Pepijn H van der Voort, Peter E Polak, Sylvie F A M S de Jong, Geert Smits, Jos Dijkmans, Hareld M C Kemps, Lukas R C Dekker and 1 more

Abstract read
In one paragraph

Article in Journal of arrhythmia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luc J H J TheunissenMáxima Medical Center Veldhoven The Netherlands.
Henricus-Paul CremersNetherlands Heart Network Eindhoven The Netherlands.ORCID https://orcid.org/0000-0003-3059-296X
Dennis van VeghelNetherlands Heart Network Eindhoven The Netherlands.
Pepijn H van der VoortCatharina Hospital Eindhoven Eindhoven The Netherlands.
Peter E PolakSt. Anna Hospital Geldrop The Netherlands.
Sylvie F A M S de JongElkerliek Hospital Helmond The Netherlands.
Geert SmitsGP Organization PoZoB Helmond The Netherlands.
Jos DijkmansGP Organization DOH Eindhoven The Netherlands.
Hareld M C KempsMáxima Medical Center Veldhoven The Netherlands.
Lukas R C DekkerCatharina Hospital Eindhoven Eindhoven The Netherlands.
Jeroen A A van de PolNetherlands Heart Network Eindhoven The Netherlands.ORCID https://orcid.org/0000-0002-2106-5634

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn this study, the relationship between AF-related quality of life (AFEQT) at baseline in AF-patients and the improvement on perceived symptoms and general state of health (EHRA, European Heart Rhythm Association score) at 12 months was assessed across predefined age categories.

methodsBetween November 2014 and October 2019 patients diagnosed with AF de novo in four hospitals embedded within the Netherlands Heart Network were prospectively followed for 12 months. These AF-patients were categorized into quartiles based on their AFEQT score at diagnosis and EHRA score was measured at diagnosis and 12 months of follow-up. Stratified analyses were performed using age categories (<65 vs. ≥65 years; <75 vs. ≥75 years).

resultsIn total, 203/483 (42.0%) AF-patients improved in EHRA score after 12 months of follow-up. AF-patients in the lowest AFEQT quartile were more likely to improve, compared to patients in the highest AFEQT quartile (OR [95%CI]:4.73 [2.63-8.50]). Furthermore, patients ≥65 years and patients <75 years at diagnosis with lower AFEQT scores at baseline were most likely to improve in EHRA score after 12 months, compared to similarly aged patients with higher AFEQT scores at baseline.

conclusionThe present study indicates that AF-patients with a lower quality of life at diagnosis were most likely to improve their EHRA score after 12 months. This effect was most prominent in patients ≥65 years of age and patients <75 years of age, compared to patients >65 and ≥75 years, respectively. Future research should focus on further defining characteristics of these age groups to enable the implementation of age-tailored treatment.

Indexed as

atrial fibrillationquality of liferisk factorsrisk stratificationsymptom improvement

Identifiers

PMID35222750
PMCPMC8851594

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.