Evidence map›Paper›PMID 35222588›Full record

ArticleAfrican health sciences2021

Polymorphism in the

Amrita Bhat, Gh Rasool Bhat, Sonali Verma, Ruchi Shah, Ashna Nagpal, Bhanu Sharma, Divya Bakshi, Jyotsna Suri, Supinder Singh, Mukesh Tanwar and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Amrita BhatCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Gh Rasool BhatCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Sonali VermaCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Ruchi ShahCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Ashna NagpalCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Bhanu SharmaCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Divya BakshiCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Jyotsna SuriDepartment of Pathology, GMC, Jammu, India.
Supinder SinghDepartment of Medicine, ASCOMS, Sidhra, J&K, India, 182320.
Mukesh TanwarDepartments of Genetics, Maharishi Dayanand University, Rohtak, Haryana, India.
Samantha VaishnaviDepartment of Botany, Central University of Jammu, J&K, India.
Audesh BhatCentre for Molecular Biology, Central University of Jammu, J&K, India.
Rakesh KumarCancer Genetics Research Group, School of Biotechnology, Shri Mata Vaishno Devi University, Katra, J&K, India,182320.
Shri Mata Vaishno Devi University · INUniversity of Jammu · INAscom (Switzerland) · CHGovernment Medical College · INMaharshi Dayanand University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of single nucleotide polymorphism rs10937405 (C>T) of the

objectivesIn the present study, we investigated the association of genetic variant rs10937405 with leukemic in the Jammu and Kashmir population.

methodsA total of 588 subjects, (188 cases and 400 controls) were recruited for the study. The rs10937405 variant was genotyped by using the real-time based TaqMan assay.

resultsA statistically significant association was observed between the rs10937405 and leukemia [OR of 1.94 (95% CI 1.51-2.48), p=1.2x10-6].

conclusionThe current study concludes that the rs10937405 variant is a risk factor for the development of leukemia in the population of Jammu and Kashmir, North India. However, it would be interesting to explore the contribution of this variant in other cancers as well. Our findings will help in the development of diagnostic markers for leukemia in the studied population and potentially for other North Indian populations.

Indexed as

Genetic Predisposition to DiseaseLeukemiaAsian PeopleCase-Control StudiesGenotypeHumansIndiaPolymorphism, Single NucleotideTranscription FactorsTumor Suppressor ProteinsTP63 protein, humanTranscription FactorsTumor Suppressor ProteinsGenome wide association studies (GWAS)Jammu and Kashmir (J &K)LeukemiaLinkage Disequilibrium (LD)North Indian populationSingle Nucleotide Polymorphism (SNPs)Tumour suppressor (TP63)

Identifiers

PMID35222588
PMCPMC8843251
OpenAlexW3202646372

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.