Evidence map›Paper›PMID 35222520›Full record

ArticleFrontiers in genetics2021

Educational Attainment and Ischemic Stroke: A Mendelian Randomization Study.

Luyan Gao, Kun Wang, Qing-Bin Ni, Hongguang Fan, Lan Zhao, Lei Huang, Mingfeng Yang, Huanming Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Luyan GaoDepartment of Neurology, Tianjin Fourth Central Hospital, The Fourth Central Hospital Affilicated to Nankai University, The Fourth Central Clinical College of Tianjin Medical University, Tianjin, China.
Kun WangTaishan Academy of Medical Sciences, Taian City Central Hospital, Taian, China.
Qing-Bin NiTaishan Academy of Medical Sciences, Taian City Central Hospital, Taian, China.
Hongguang FanDepartment of Neurology, Tianjin Fourth Central Hospital, The Fourth Central Hospital Affilicated to Nankai University, The Fourth Central Clinical College of Tianjin Medical University, Tianjin, China.
Lan ZhaoDepartment of Neurology, Tianjin Fourth Central Hospital, The Fourth Central Hospital Affilicated to Nankai University, The Fourth Central Clinical College of Tianjin Medical University, Tianjin, China.
Lei HuangDepartment of Neurology, Tianjin Fourth Central Hospital, The Fourth Central Hospital Affilicated to Nankai University, The Fourth Central Clinical College of Tianjin Medical University, Tianjin, China.
Mingfeng YangSecond Affiliated Hospital, Brain Science Institute, Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Huanming LiDepartment of Cardiovascular, Tianjin Fourth Central Hospital, The Fourth Central Hospital Affilicated to Nankai University, The Fourth Central Clinical College of Tianjin Medical University, Tianjin, China.
Nankai University · CNTaian City Central Hospital · CNTianjin Medical University · CNShandong First Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Observational studies have evaluated the potential association of socioeconomic factors such as higher education with the risk of stroke but reported controversial findings. The objective of our study was to evaluate the potential causal association between higher education and the risk of stroke. Here, we performed a Mendelian randomization analysis to evaluate the potential association of educational attainment with ischemic stroke (IS) using large-scale GWAS datasets from the Social Science Genetic Association Consortium (SSGAC, 293,723 individuals), UK Biobank (111,349 individuals), and METASTROKE consortium (74,393 individuals). We selected three Mendelian randomization methods including inverse-variance-weighted meta-analysis (IVW), weighted median regression, and MR-Egger regression. IVW showed that each additional 3.6-year increase in years of schooling was significantly associated with a reduced IS risk (OR = 0.54, 95% CI: 0.41-0.71, and

Indexed as

educational attainmentgenome-wide association studiesischaemic strokeMendelian randomizationstroke

Identifiers

PMID35222520
PMCPMC8876515
OpenAlexW4211259114

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.