Evidence map›Paper›PMID 35222432›Full record

ReviewFrontiers in immunology2022

Cohesin-Mediated Chromatin Interactions and Autoimmunity.

Venkataragavan Chandrasekaran, Nina Oparina, Maria-Jose Garcia-Bonete, Caroline Wasén, Malin C Erlandsson, Eric Malmhäll-Bah, Karin M E Andersson, Maja Jensen, Sofia T Silfverswärd, Gergely Katona and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Co-Occurrence ofInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Somatic mosaicism inFrontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Venkataragavan ChandrasekaranDepartment of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Nina OparinaRheumatology Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden.
Maria-Jose Garcia-BoneteDepartment of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Caroline WasénAnn Romney Center for Neurologic Diseases, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, United States.
Malin C ErlandssonDepartment of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Eric Malmhäll-BahDepartment of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Karin M E AnderssonDepartment of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Maja JensenDepartment of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden.
Sofia T SilfverswärdDepartment of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Gergely KatonaDepartment of Chemistry and Molecular Biology, Faculty of Science, University of Gothenburg, Gothenburg, Sweden.
Maria I BokarewaDepartment of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
University of Gothenburg · SESahlgrenska University Hospital · SEBrigham and Women's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-binding factor, it ensures insulator activity to organize enhancers and promoters within regulatory chromatin. Homozygous mutations and dysfunction of individual cohesin proteins are embryonically lethal in humans and mice, which limits

Indexed as

ChromatinGenome-Wide Association StudyAnimalsAutoimmunityCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsMiceCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinsautoimmunityCCCTC-binding factorcohesingenome organizationimmune signaling

Identifiers

PMID35222432
PMCPMC8866859
OpenAlexW4211033646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.