ArticleFrontiers in immunology2022
Increased Levels of Interleukin-36 in Obesity and Type 2 Diabetes Fuel Adipose Tissue Inflammation by Inducing Its Own Expression and Release by Adipocytes and Macrophages.
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Change in Adipokines and Gastrointestinal Hormones After Bariatric Surgery: a Meta-analysis.Obesity surgery · 2023Pooled it
- Elevated interleukin-36γ and gene polymorphisms implicate novel risk in essential hypertension.Immunogenetics · 2026Article
- An Exploratory Study to Identify Factors Associated with Recurrence of Generalized Pustular Psoriasis Flares in Adult Patients in Japan.Acta dermato-venereologica · 2026Article
- Obesity and type 2 diabetes as chronic inflammation: how does the cytokine evidence align?Frontiers in endocrinology · 2026Review
- Impact of chronic hyperglycaemia on the coronary microcirculation - benefits of targeting IL-36 and diet reversal.Basic research in cardiology · 2025Article
- Increased IL- 36γ in visceral adipose tissue as a key mediator of obesity-driven inflammation in colon cancer.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Increased expression of IL-1β in adipose tissue in obesity influences the development of colon cancer by promoting inflammation.Journal of physiology and biochemistry · 2025Article
- Complex networks interactions between bioactive compounds and adipose tissue vis-à-vis insulin resistance.Frontiers in endocrinology · 2025Article
- Increased expression levels of PIEZO1 in visceral adipose tissue in obesity and type 2 diabetes are triggered by mechanical forces and are associated with inflammation.Molecular medicine (Cambridge, Mass.) · 2024Article
- Butyrate and tributyrin reduce LPS-induced inflammatory cytokine production from human visceral fat.International journal of obesity (2005) · 2024Article
- Serum IL-36β levels are associated with Insulin sensitivity in paediatric patients with obesity.International journal of obesity (2005) · 2024Article
- Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages.Immunometabolism (Cobham, Surrey) · 2023Review
- Obesity and the risk of cardiometabolic diseases.Nature reviews. Cardiology · 2023Review
- Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4Cardiovascular diabetology · 2023Article
- Association between red blood cell distribution width-to-albumin ratio and diabetic retinopathy.Journal of clinical laboratory analysis · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-36 is a recently described cytokine with well-known functions in the regulation of multiple inflammatory diseases. Since no data exists on how this cytokine regulates adipose tissue (AT) homeostasis, we aimed to explore the function of a specific isoform, IL-36γ, an agonist, in human obesity and obesity-associated type 2 diabetes as well as in AT inflammation and fibrosis. Plasma IL-36γ was measured in 91 participants in a case-control study and the effect of weight loss was evaluated in 31 patients with severe obesity undergoing bariatric surgery. Gene expression levels of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.