Evidence map›Paper›PMID 35222381›Full record

ArticleFrontiers in immunology2022

Intravenous Immunoglobulin Therapy Restores the Quantity and Phenotype of Circulating Dendritic Cells and CD4

Nana Wang, Zhongyue Chen, Fan Zhang, Qianwen Zhang, Ling Sun, Haitao Lv, Bo Wang, Jie Shen, Xufang Zhou, Feiyan Chen and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Nana WangDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Zhongyue ChenDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Fan ZhangDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Qianwen ZhangDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Ling SunDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Haitao LvDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Bo WangDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Jie ShenDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Xufang ZhouDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Feiyan ChenDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Binwei ZhangDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Lijun MengDepartment of Hematology, Children's Hospital of Soochow University, Suzhou, China.
Huiting ZhouPediatric Research Institute of Soochow University, Suzhou, China.
ZhenJiang BaiDepartment of Pediatric Intensive Care Unit, Children Hospital of Soochow University, Suzhou, China.
Jie HuangDepartment of Cardiology, Children's Hospital of Soochow University, Suzhou, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Intravenous immunoglobulin (IVIG) showed its therapeutic efficacy on Kawasaki disease (KD). However, the mechanisms by which it reduces systemic inflammation are not completely understood. Dendritic cells (DCs) and T cells play critical roles in the pathogenic processes of immune disorders. Assessing the quantity of DC subsets and T cells and identifying functional molecules present on these cells, which provide information about KD, in the peripheral blood may provide new insights into the mechanisms of immunoglobulin therapy. Methods: In total, 54 patients with KD and 27 age-matched healthy controls (HCs) were included in this study. The number, percentage, and phenotype of DC subsets and CD4 Results: Patients with KD exhibited fewer peripheral DC subsets and CD4 Conclusions: pDCs and CD1c

Indexed as

Immunoglobulins, IntravenousMucocutaneous Lymph Node SyndromeCD4-Positive T-LymphocytesDendritic CellsHumansInflammationPhenotypeT-LymphocytesImmunoglobulins, IntravenousCD4+ T cellsdendritic cellsimmune disordersintravenous immunoglobulinKawasaki disease

Identifiers

PMID35222381
PMCPMC8866170
OpenAlexW4225996302

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.