Evidence map›Paper›PMID 35222352›Full record

ArticleFrontiers in immunology2021

HIV-Sheltering Platelets From Immunological Non-Responders Induce a Dysfunctional Glycolytic CD4

Aiwei Zhu, Fernando Real, Jaja Zhu, Ségolène Greffe, Pierre de Truchis, Elisabeth Rouveix, Morgane Bomsel, Claude Capron

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04062825 unknown statusnot on this map

Interaction of HIV/Platelets and HIV-platelets/Lymphocytes in HIV Patients Under cART Treatment But Immunological Non Responders

TypeobservationalSponsorAssistance Publique - Hôpitaux de ParisRan2020 to 2025Enrolled240ConditionsHIV Seropositivity
NCT06889142 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Proof-of-Concept Study: Investigating the Impact of NMN Supplementation on CD4+ T Cell Recovery in Virologically Suppressed HIV Patients With Immunological Failure

TypeinterventionalSponsorTriHealth Inc.Ran2025 to 2025Enrolled7ConditionsHuman Immunodeficiency VirusArmsNicotinamide Mononucleotide
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Aiwei ZhuMucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université de Paris, Paris, France.
Fernando RealMucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université de Paris, Paris, France.
Jaja ZhuService d'Hématologie, Hôpital Ambroise Paré (AP-HP), Boulogne-Billancourt, France.
Ségolène GreffeService d'Hématologie, Hôpital Ambroise Paré (AP-HP), Boulogne-Billancourt, France.
Pierre de TruchisUniversité Versailles Saint Quentin-en-Yvelines (UVSQ), Université Paris Saclay, Versailles, France.
Elisabeth RouveixService d'Hématologie, Hôpital Ambroise Paré (AP-HP), Boulogne-Billancourt, France.
Morgane BomselMucosal Entry of HIV and Mucosal Immunity, Institut Cochin, Université de Paris, Paris, France.
Claude CapronService d'Hématologie, Hôpital Ambroise Paré (AP-HP), Boulogne-Billancourt, France.
Assistance Publique – Hôpitaux de Paris · FRInserm · FRHôpital Ambroise-Paré · FRInstitut Cochin · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FRUniversité Paris-Saclay · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunological non-responders (InRs) are HIV-infected individuals in whom the administration of combination antiretroviral therapy (cART), although successful in suppressing viral replication, cannot properly reconstitute patient circulating CD4

Indexed as

Blood PlateletsHIV InfectionsCD4 Lymphocyte CountCD4-Positive T-LymphocytesGlycolysisHumansCD4+ T-cell metabolismglycolysisHIV-1immunological failureplateletsvirus-containing platelets

Identifiers

PMID35222352
PMCPMC8873581
OpenAlexW4211095858

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.