Evidence map›Paper›PMID 35222280›Full record

ReviewFrontiers in endocrinology2022

Multipotent Mesenchymal Stromal Cells Interact and Support Islet of Langerhans Viability and Function.

Naomi Koehler, Leo Buhler, Bernhard Egger, Carmen Gonelle-Gispert

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Advancements in diabetes research and stem cell therapy: a concise review.Journal of diabetes and metabolic disorders · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Applications of Genome-Editing Technologies for Type 1 Diabetes.International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Naomi KoehlerSurgical Research Unit, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Leo BuhlerDepartment of Surgery, Cantonal Hospital Fribourg, Fribourg, Switzerland.
Bernhard EggerSurgical Research Unit, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Carmen Gonelle-GispertSurgical Research Unit, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
University of Fribourg · CHFribourg Development Agency · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes (T1D) is a widespread disease, affecting approximately 41.5 million people worldwide. It is generally treated with exogenous insulin, maintaining physiological blood glucose levels but also leading to long-term therapeutic complications. Pancreatic islet cell transplantation offers a potential alternative treatment to insulin injections. Shortage of human organ donors has raised the interest for porcine islet xenotransplantation. Neonatal porcine islets are highly available, can proliferate and mature

Indexed as

Islets of Langerhans TransplantationMesenchymal Stem Cell TransplantationAnimalsCell SurvivalCoculture TechniquesDiabetes Mellitus, Type 1Graft SurvivalHumansImmunomodulationIslets of LangerhansMesenchymal Stem CellsNeovascularization, PhysiologicSwineTransplantation, Heterologouscell encapsulationdiabetesMSCneonatal porcine isletsxenotransplantion

Identifiers

PMID35222280
PMCPMC8864309
OpenAlexW4210943302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.