Evidence map›Paper›PMID 35222255›Full record

ArticleFrontiers in neurology2022

Diagnostic Delay and Its Predictors in Cluster Headache.

Byung-Su Kim, Pil-Wook Chung, Byung-Kun Kim, Mi Ji Lee, Min Kyung Chu, Jin-Young Ahn, Dae Woong Bae, Tae-Jin Song, Jong-Hee Sohn, Kyungmi Oh and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Observational
  5. Article
  6. Review
  7. Review
  8. Health equity, care access and quality in headache - part 2.The journal of headache and pain · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 15 institutions in 1 country.

Byung-Su KimDepartment of Neurology, Daejin Medical Center, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Pil-Wook ChungDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Byung-Kun KimDepartment of Neurology, Eulji Hospital, Eulji University, Seoul, South Korea.
Mi Ji LeeDepartment of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Min Kyung ChuDepartment of Neurology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Jin-Young AhnDepartment of Neurology, Seoul Medical Center, Seoul, South Korea.
Dae Woong BaeDepartment of Neurology, College of Medicine, The Catholic University of Korea, Suwon, South Korea.
Tae-Jin SongDepartment of Neurology, Seoul Hospital, Ewha Womans University, College of Medicine, Seoul, South Korea.
Jong-Hee SohnDepartment of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea.
Kyungmi OhDepartment of Neurology, Korea University College of Medicine, Seoul, South Korea.
Daeyoung KimDepartment of Neurology, Chungnam National University College of Medicine, Daejeon, South Korea.
Jae-Moon KimDepartment of Neurology, Chungnam National University College of Medicine, Daejeon, South Korea.
Jeong Wook ParkDepartment of Neurology, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu, South Korea.
Jae Myun ChungDepartment of Neurology, Inje University College of Medicine, Seoul, South Korea.
Heui-Soo MoonDepartment of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Soohyun ChoDepartment of Neurology, Eulji University, Uijeongbu, South Korea.
Jong-Geun SeoDepartment of Neurology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Soo-Kyoung KimDepartment of Neurology, Gyeongsang National University College of Medicine and Gyeonsang National University Hospital, Jinju, South Korea.
Yun-Ju ChoiDr. Choi's Neurology Clinic, Jeonju, South Korea.
Kwang-Yeol ParkDepartment of Neurology, Chung-Ang University Hospital, Seoul, South Korea.
Chin-Sang ChungDepartment of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Soo-Jin ChoDepartment of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, South Korea.
Eulji University · KRSamsung Medical Center · KRChungnam National University · KRKangbuk Samsung Hospital · KRChung-Ang University Hospital · KREwha Womans University · KRGyeongsang National University Hospital · KRHallym University · KRInje University · KRKorea University · KRKyungpook National University · KRSeoul Medical Center · KRSuwon Catholic University · KRThe Catholic University of Korea Uijeongbu St. Mary's Hospital · KRYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCluster headache (CH) is a rare, primary headache disorder, characterized of excruciating, strictly one-sided pain attacks and ipsilateral cranial autonomic symptoms. Given the debilitating nature of CH, delayed diagnosis can increase the disease burden. Thus, we aimed to investigate the diagnostic delay, its predictors, and clinical influence among patients with CH.

methodsData from a prospective multicenter CH registry over a 4-year period were analyzed. CH was diagnosed according to the International Classification of Headache Disorders (ICHD)-3 criteria, and diagnostic delay of CH was assessed as the time interval between the year of the first onset and the year of CH diagnosis. Patients were classified into three groups according to the tertiles of diagnostic delay (1st tertile, <1 year; 2nd tertile, 1-6 years; and 3rd tertile, ≥7 years).

resultsOverall, 445 patients were evaluated. The mean duration of diagnosis delay was 5.7 ± 6.7 years, (range, 0-36 years). Regarding the age of onset, majority of young patients (age <20 years) belonged to the third tertile (60%), whereas minority of old patients (>40 years) belonged to the third tertile (9.0%). For year of onset, the proportion of patients in the 3rd tertile was the highest for the groups before the publication year of the ICHD-2 (74.7%) and the lowest for the groups after the publication year of the ICHD-3 beta version (0.5%). Compared with the first CH, episodic CH [multivariable-adjusted odds ratio (aOR) = 5.91, 95% CI = 2.42-14.48], chronic CH (aOR = 8.87, 95% CI = 2.66-29.51), and probable CH (aOR = 4.12, 95% CI = 1.48-11.43) were associated with the tertiles of diagnostic delay. Age of onset (aOR = 0.97, 95% CI = 0.95-0.99) and PHQ-9 score (aOR = 0.96, 95% CI = 0.93-0.99) were inversely associated with the tertile of diagnostic delay. The prevalence of suicidal ideation was highest in the patients of the third tertile. The mean HIT-6 score increased significantly with the diagnostic delay (

conclusionsPatients with a younger onset of CH have a higher risk of diagnostic delay. Nevertheless, the rate of delayed diagnosis gradually improved over time and with the publication of the ICHD criteria, supporting the clinical significance of diagnostic clinical criteria and headache education to reduce the disease burden of CH.

Indexed as

cluster headachedelayed diagnosisheadacheKoreaprimary headache disorder

Identifiers

PMID35222255
PMCPMC8866826
OpenAlexW4210989758

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.