Evidence map›Paper›PMID 35222248›Full record

ArticleFrontiers in neurology2022

Patient-Reported Anxiety/Depression After Endovascular Thrombectomy: A

Ping Zhang, Hong-Jian Shen, Lei Chen, Xuan Zhu, Min-Min Zhang, Yi Jiang, Peng-Fei Yang, Lei Zhang, Peng-Fei Xing, Xiao-Fei Ye and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03469206 (Parallel Group, Randomized Clinical Trial of Direct Intra-arterial Thrombectomy Versus Intravenous Thrombolysis With Intra-arterial Thrombectomy for Patients With Large Vessel Occlusion of the Anterior Circulation), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03469206 nacompletednot on this map

Parallel Group, Randomized Clinical Trial of Direct Intra-arterial Thrombectomy Versus Intravenous Thrombolysis With Intra-arterial Thrombectomy for Patients With Large Vessel Occlusion of the Anterior Circulation

TypeinterventionalSponsorChanghai HospitalRan2018 to 2019Enrolled656ConditionsIschemic Stroke, Large Vessel Occlusion, Thrombectomy, ThrombosisArmsintra-arterial thrombectomy, Intravenous thrombolysis
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Measuring the health outcomes of Chinese ischemic stroke patients based on the data from a longitudinal multi-center study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Ping ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Hong-Jian ShenDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Lei ChenDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Xuan ZhuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Min-Min ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yi JiangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Peng-Fei YangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Lei ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Peng-Fei XingDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Xiao-Fei YeDepartment of Statistics, Naval Medical University, Shanghai, China.
Min LouDepartment of Neurology, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Cong-Guo YinDepartment of Neurology, Hangzhou First People's Hospital, Hangzhou, China.
Ben-Qiang DengDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Tao WuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Yong-Wei ZhangDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Jian-Min LiuDepartment of Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China.
Second Military Medical University · CNChanghai Hospital · CNHangzhou First People's Hospital · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the effect of endovascular thrombectomy (EVT) alone vs. EVT after an intravenous (IV) alteplase of ischemic stroke on a patient-reported anxiety/depression, and to identify predictors of patient-reported anxiety/depression by analyzing data from Direct Intraarterial Thrombectomy in Order to Revascularize the patients with Acute Ischemic Stroke with a Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals: a Multicenter Randomized Clinical Trial (DIRECT-MT).

methodsPatients with acute ischemic stroke (AIS), triggered by a large-vessel occlusion in the anterior circulation, were randomly allocated to undergo an EVT after IV alteplase (combination-therapy group) or an EVT alone (EVT-alone group) at a 1:1 ratio in DIRECT-MT. Patients in both groups were followed up for 90 days (±14 days) after stroke using a structured modified Ranking Scale (mRS), a Barthel Index (BI), and a 5-Dimensional European Quality of Life Scale (EQ-5D-5L). Patients who returned EQ-5D-5L were included. The EQ-5D-5L anxiety/depression dimension was used to analyze the patient-reported anxiety/depression. First, differences in patient-reported anxiety/depression were compared between the combination-therapy group and the EVT-alone group. Then, the baseline and influencing factors between the anxiety/depression group and no anxiety/depression group were analyzed using univariate regression analysis. Finally, variables with

results

conclusionsPatient-reported anxiety/depression may suggest that there is a benefit to administering intravenous alteplase before EVT. It may also indicate that it is better to provide IV alteplase before EVT, rather than EVT alone according to patient-reported anxiety/depression. Future research should consider not only the motor function impairments but also the patient-reported mental problems as measures of treatment efficacy in patients with stroke (DIRECT-MT ClinicalTrials.gov number, NCT03469206).

Indexed as

anxietydepressionischemic strokethrombectomythrombolysis

Identifiers

PMID35222248
PMCPMC8864177
OpenAlexW4210946541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.