SynthesisFrontiers in aging neuroscience2022
Association of Headache Disorders and the Risk of Dementia: Meta-Analysis of Cohort Studies.
Synthesis in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 8 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Chronic Pain and the Risk of Dementia: A Systematic Review and Meta-Analysis.Current pain and headache reports · 2026Pooled it
- Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization.Brain and behavior · 2026Pooled it
- Risk prediction models for sarcopenia among community-dwelling older adults in China: a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Pooled it
- Non-Genetic Risk Factors of Alzheimer's Disease: An Updated Umbrella Review.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Prevalence and clinical characteristics of white matter hyperintensities in Migraine: A meta-analysis.NeuroImage. Clinical · 2023Pooled it
- Association of overweight, obesity and risk of urinary incontinence in middle-aged and older women: a meta epidemiology study.Frontiers in endocrinology · 2023Pooled it
- Risk of dry eye in headache patients: a systematic review and meta-analysis.Annals of medicine · 2022Pooled it
- Migraine and the Risk of Dementia in the General Population.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Headache associated with adverse cognitive trajectories in Chinese aging cohort: a group-based trajectory modeling study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Comparison of Syn T2-FLAIR and Syn DIR with conventional T2-FLAIR in displaying white matter hyperintensities in migraine patients.Neuroradiology · 2025Article
- Article
- Mind the Metabolic Gap: Bridging Migraine and Alzheimer's disease through Brain Insulin Resistance.Aging and disease · 2024Review
- Role of obesity in lower mortality risk in sepsis: a meta-analysis of observational studies.American journal of translational research · 2024Review
- Prevalence of Dementia and Cognitive Impairment in East Africa Region: A Scoping Review of Population-Based Studies and Call for Further Research.Journal of Alzheimer's disease : JAD · 2024Article
- Prevalence of dementia and its association with central nervous system infections among older persons in northern Uganda: cross-sectional community-based study.BMC geriatrics · 2023Article
- Acupuncture Treatment is Associated with Reduced Dementia Risk in Patients with Migraine: A Propensity-Score-Matched Cohort Study of Real-World Data.Neuropsychiatric disease and treatment · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this meta-analysis is to assess whether there is an association between headache disorders and all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD).
methodsPubMed, Cochrane Library, Embase, and Web of Science were searched for cohort studies published from database inception to October 8, 2021, using medical subject headings (MeSH) and keywords. All statistical analyses were performed using Stata statistical software version 14.0. If
resultsThis meta-analysis included 12 cohort studies covering 465,358 individuals, which were published between 2001 and 2020. The pooling analysis shows that a history of any headache disorder is associated with an increased risk of all-cause dementia (OR = 1.35; 95% CI: 1.21-1.50;
conclusionsOur meta-analysis shows that any headache disorder increases the risk of all-cause dementia, AD, or VaD. These findings provide evidence that headache should be recognized as an independent risk factor for dementia, AD, or VaD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.