ArticleFrontiers in aging neuroscience2022
Bidirectional Longitudinal Study of Frailty and Depressive Symptoms Among Older Chinese Adults.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Associations of transitions in frailty and depressive symptoms with the risk of cardiovascular disease in adults with hypertension: findings from three aging cohorts.The journal of nutrition, health & aging · 2026Article
- Cross-Sectional Associations of Cognitive Function, Frailty, Depressive Symptoms, and Self-Care Dependence in Residents of a Long-Term Care Institution.Healthcare (Basel, Switzerland) · 2026Article
- A High Geriatric Depression Scale Score on Admission to Hospital Predicts a Worse Clinical Frailty Scale Score After Discharge.Geriatrics & gerontology international · 2026Article
- Commentary on "A High Geriatric Depression Scale Score on Admission to Hospital Predicts a Worse Clinical Frailty Scale Score After Discharge".Geriatrics & gerontology international · 2026Article
- Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Association between frailty status and depression among older adults: panel data analysis of three longitudinal cohort studies.BMC public health · 2026Article
- [Actor-Partner Interdependence Model Analysis of the Relationship Between Individual Social Capital and Depressive Symptoms Among Older Couples Across Different Socioeconomic Statuses].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Casual associations between frailty and nine mental disorders: bidirectional Mendelian randomisation study.BJPsych open · 2025Article
- Exploring the Causal Relationship Between Frailty and Chronic Obstructive Pulmonary Disease: Insights From Bidirectional Mendelian Randomization and Mediation Analysis.International journal of chronic obstructive pulmonary disease · 2025Article
- Causal relationship between genetically predicted mental disorders and frailty: a bidirectional and multivariable mendelian randomization study.BMC psychiatry · 2024Article
- Changes in frailty and depressive symptoms among middle-aged and older Chinese people: a nationwide cohort study.BMC public health · 2024Article
- The relationship between sleep duration and frailty: findings from the China Health and Retirement Longitudinal Study.Frontiers in public health · 2024Article
- The bidirectional relationship between sarcopenia and disability in China: a longitudinal study from CHARLS.Frontiers in public health · 2024Article
- Plant-Based Diet Indices and Their Association with Frailty in Older Adults: A CLHLS-Based Cohort Study.Nutrients · 2023Article
- Frailty, cognitive impairment, and depressive symptoms in Chinese older adults: an eight-year multi-trajectory analysis.BMC geriatrics · 2023Article
- Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study.Journal of cachexia, sarcopenia and muscle · 2023Article
- Frailty and medication adherence among older adult patients with hypertension: a moderated mediation model.Frontiers in public health · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveFrailty and depression, as two common conditions among older adults in China, have been shown to be closely related to each other. The aim of this study was to investigate the bidirectional effects between frailty and depressive symptoms in Chinese population.
methodsThe bidirectional effect of frailty with depressive symptoms was analyzed among 5,303 adults ≥ 60 years of age from the China Health and Retirement Longitudinal Study (CHARLS). Phenotype and a frailty index were used to measure frailty. Depressive symptoms were evaluated using the Epidemiological Studies Depression Scale (CES-D). Logistic regression and Cox proportional hazard regression models were used to determine the bidirectional effects of frailty and depressive symptoms in cross-sectional and cohort studies, respectively. Subgroup and sensitivity analyses were further used to further verify the associations.
resultsIn the cross-sectional study, the multivariate-adjusted ORs (95% CIs) for depressive symptoms among pre-frail and frail adults, as defined by the frailty index and phenotype, were 3.05 (2.68-3.49), and 9.78 (8.02-12.03), respectively. Depressed participants showed higher risks of pre-frailty and frailty [frailty index, 3.07 (2.69-3.50); and phenotypic frailty, 9.95 (8.15-12.24)]. During follow-up, the multivariate-adjusted HRs (95% CIs) for depressive symptoms among pre-frail and frail participants, as defined by the frailty index and phenotype, were 1.38 (1.22-1.57), and 1.30 (1.14-1.48), respectively. No significant relationship existed between baseline depressive symptoms and the incidence of frailty. Moreover, the results from subgroup and sensitivity analyses were consistent with the main results.
conclusionAlthough a cross-sectional bidirectional association between depressive symptom and frailty has been observed in older (≥60 years old) Chinese adults, frailty may be an independent predictor for subsequent depression. Moreover, no effect of depressive symptoms on subsequent frailty was detected. Additional bidirectional studies are warranted in China.
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