Evidence map›Paper›PMID 35221915›Full record

ArticleFrontiers in molecular neuroscience2022

Single-Cell RNA Sequencing Characterizes the Molecular Heterogeneity of the Larval Zebrafish Optic Tectum.

Annalie Martin, Anne Babbitt, Allison G Pickens, Brett E Pickett, Jonathon T Hill, Arminda Suli

Abstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Zebrafish models of human-duplicatedbioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Annalie MartinDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States.
Anne BabbittDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States.
Allison G PickensDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States.
Brett E PickettDepartment of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
Jonathon T HillDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States.
Arminda SuliDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, United States.

Funding

Identifying and characterizing auditory-visual multisensory neurons in the optic tectum of zebrafish larvaeR15HD095737 · NICHD · BRIGHAM YOUNG UNIVERSITY · PI SULI, ARMINDA · 2019 to 2019
$450k
NICHD NIH HHS R15 HD095737
6 · The paper itself

Abstract

The optic tectum (OT) is a multilaminated midbrain structure that acts as the primary retinorecipient in the zebrafish brain. Homologous to the mammalian superior colliculus, the OT is responsible for the reception and integration of stimuli, followed by elicitation of salient behavioral responses. While the OT has been the focus of functional experiments for decades, less is known concerning specific cell types, microcircuitry, and their individual functions within the OT. Recent efforts have contributed substantially to the knowledge of tectal cell types; however, a comprehensive cell catalog is incomplete. Here we contribute to this growing effort by applying single-cell RNA Sequencing (scRNA-seq) to characterize the transcriptomic profiles of tectal cells labeled by the transgenic enhancer trap line

Indexed as

cell type identificationmolecular characterizationoptic tectumsingle-cell RNA sequencingzebrafish

Identifiers

PMID35221915
PMCPMC8869500

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.