Evidence map›Paper›PMID 35221889›Full record

SynthesisFrontiers in neuroscience2021

Non-invasive Brain Stimulation for Neuropathic Pain After Spinal Cord Injury: A Systematic Review and Network Meta-Analysis.

Lingling Li, Hailiang Huang, Ying Yu, Yuqi Jia, Zhiyao Liu, Xin Shi, Fangqi Wang, Tingting Zhang

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05645003 (Effect of Repetative Transcranial Magnetic Stimulation Therapy on Neuropathic Pain in Patients With Spinal Cord Injury), which is not on this map. Cited by 16 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 5 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05645003 narecruitingnot on this mapstarted 2022, after this paper: background citation

Effect of Repetative Transcranial Magnetic Stimulation Therapy on Neuropathic Pain in Patients With Spinal Cord Injury

TypeinterventionalSponsorAfyonkarahisar Health Sciences UniversityRan2022 to 2026Enrolled60ConditionsSpinal Cord Injuries, Neuropathic Pain, Neurological Diseases or ConditionsArmsHigh-frequency real-time rTMS protocol, Sham rTMS Protocol
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Comparative efficacy of different noninvasive brain stimulation protocols on upper-extremity motor function and activities of daily living after stroke: a systematic review and network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Narrative review of current neuromodulation modalities for spinal cord injury.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lingling LiCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Hailiang HuangCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Ying YuInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China.
Yuqi JiaCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Zhiyao LiuCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Xin ShiCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Fangqi WangCollege of Rehabilitation Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Tingting ZhangCollege of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, China.
Shandong University of Traditional Chinese Medicine · CNHebei University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to systematically evaluate the effect of non-invasive brain stimulation (NIBS) on neuropathic pain (NP) after spinal cord injury and compare the effects of two different NIBS.

methodsRandomized controlled trials (RCTs) about the effect of NIBS on NP after spinal cord injury (SCI) were retrieved from the databases of PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang Data, VIP, and CBM from inception to September 2021. The quality of the trials was assessed, and the data were extracted according to the Cochrane handbook of systematic review. Statistical analysis was conducted with Stata (version 16) and R software (version 4.0.2).

resultsA total of 17 studies involving 507 patients were included. The meta-analysis showed that NIBS could reduce the pain score (SMD = -0.84, 95% CI -1.27 -0.40,

conclusionNIBS can relieve NP after SCI. The effect of rTMS on NP is superior to that of tDCS. We suggest that the rTMS parameters are 80-120% resting motion threshold and 5-20 Hz, while the tDCS parameters are 2 mA and 20 min. However, it is necessary to carry out more large-scale, multicenter, double-blind, high-quality RCT to explore the efficacy and mechanism of NIBS for NP after SCI.

Indexed as

network meta-analysisneuropathic painnon-invasive brain stimulationspinal cord injurysystematic review

Identifiers

PMID35221889
PMCPMC8873374
OpenAlexW4211088421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.