Evidence map›Paper›PMID 35221866›Full record

ArticleTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2022

Variances in Antiviral Memory T-Cell Repertoire of CD45RA- and CD62L-Depleted Lymphocyte Products Reflect the Need of Individual T-Cell Selection Strategies to Reduce the Risk of GvHD while Preserving Antiviral Immunity in Adoptive T-Cell Therapy.

Caroline Mangare, Sabine Tischer-Zimmermann, Agnes Bonifacius, Sebastian B Riese, Anna Christina Dragon, Rainer Blasczyk, Britta Maecker-Kolhoff, Britta Eiz-Vesper

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. "Attack!" Cellular Therapies to Attack Pathogens and Tumors.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Caroline MangareInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Sabine Tischer-ZimmermannInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Agnes BonifaciusInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Sebastian B RieseInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Anna Christina DragonInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Rainer BlasczykInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Britta Maecker-KolhoffDepartment of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Britta Eiz-VesperInstitute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
Medizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionViral infections and reactivations still remain a cause of morbidity and mortality after hematopoietic stem cell transplantation due to immunodeficiency and immunosuppression. Transfer of unmanipulated donor-derived lymphocytes (DLI) represents a promising strategy for improving cellular immunity but carries the risk of graft versus host disease (GvHD). Depleting alloreactive naïve T cells (T

methodsT-cell responses against ppEBV_EBNA1, ppEBV_Consensus and ppAdV_Hexon within T

resultsAccording to differences in the phenotype composition, antigen-specific T-cell responses in CD45RA

conclusionTaken together, our results indicate that CD45RA depletion is a more suitable strategy for generating T

Indexed as

AlloreactivityLow precursor frequencyNaïve T-cell depletionT-cell response

Identifiers

PMID35221866
PMCPMC8832244
OpenAlexW3200364733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.