ReviewEXCLI journal2022
The effects of low-toxic herbicide Roundup and glyphosate on mitochondria.
Review in EXCLI journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Dose-Dependent Hepatic Alterations Following Glyphosate Exposure in Female Wistar Rats: Oxidative Stress, Intracellular Cyclic Nucleotide Alterations, Apoptosis, and VEGF.Cell biochemistry and biophysics · 2026Article
- Embryonic exposure to environmental levels of roundup affects neurodevelopment in zebrafish.Journal of the Endocrine Society · 2026Article
- Increasing temperature exacerbates acute toxicity effects of a glyphosate-based herbicide (Roundup) on the ostracod Cypridopsis africana.Biology open · 2026Article
- Comparative investigation of the potential of glyphosate and glyphosate-based formulations to cause oxidative stress and DNA damage in human skin and liver cell systems.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Dose-response-defined physiological framework enables comparative analysis of transcriptional response dynamics across multiple herbicides inFrontiers in plant science · 2026Article
- Cytotoxicity and genotoxicity of glyphosate and Roundup Quickpro on Chinese hamster ovary cells.Scientific reports · 2025Article
- Toxicological concerns regarding glyphosate, its formulations, and co-formulants as environmental pollutants: a review of published studies from 2010 to 2025.Archives of toxicology · 2025Review
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- Neurotoxic effects associated with chronic inhalation and oral exposure to glyphosate-based herbicide IN adult rats.Toxicology research · 2024Article
- Neuroglycome alterations of hippocampus and prefrontal cortex of juvenile rats chronically exposed to glyphosate-based herbicide.Frontiers in neuroscience · 2024Article
- Quantitative imaging and semiotic phenotyping of mitochondrial network morphology in live human cells.PloS one · 2024Article
- Effect of sublethal concentrations of glyphosate-based herbicides (Roundup Active®) on skin of the tropical frog (Dendropsophus molitor).Environmental science and pollution research international · 2023Article
- Biological effects of sub-lethal doses of glyphosate and AMPA on cardiac myoblasts.Frontiers in physiology · 2023Article
- Quantitative assessment of mitochondrial morphology relevant for studies on cellular health and environmental toxicity.Computational and structural biotechnology journal · 2023Article
- Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines.Journal of xenobiotics · 2022Review
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- Chronic dietary exposure to a glyphosate-based herbicide results in total or partial reversibility of plasma oxidative stress, cecal microbiota abundance and short-chain fatty acid composition in broiler hens.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of pesticides on the health of non-target living organisms in agricultural areas are critically important aspects for their safe use. Their release into the environment is an inevitable aspect for predicting and evaluation of the risk of their application. Roundup, a glyphosate-based herbicide, has been designed as an effective pesticide against weeds and now is the most widely used agrochemicals around the world due to its highly specific action of the biosynthesis of certain amino acids in plants. Despite it is claimed to be low toxic for not-target organisms, due to its broad application Roundup and products of its degradation were detected in organisms of diverse animals and humans. In this review, we describe animal and human studies of general adverse effects of Roundup and its principal substance glyphosate with focus on endocrine disruption, oxidative stress and behavioral disorders. At mechanistic level, we focus on the potential toxicity of the herbicide Roundup and glyphosate as effectors of bioenergetic functions of mitochondria. Their effects on mitochondrial membrane potential and oxidative phosphorylation are among described to date critical components responsible for its toxicity. Finally, we discuss general molecular mechanisms potentially involved in the interaction between glyphosate and mitochondria which to some extent are associated with generation of reactive oxygen species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.