Evidence map›Paper›PMID 35221732›Full record

ArticleJournal of experimental pharmacology2021

In Vitro Cytotoxicity and Anti-HIV Activity of Crude Extracts of

Ermias Mergia Terefe, Faith Apolot Okalebo, Solomon Derese, Joseph Muriuki, Gaber El-Saber Batiha

Open access · goldAbstract read
In one paragraph

Article in Journal of experimental pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
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  4. Secondary Metabolites fromMetabolites · 2025
    Review
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  7. Journal of experimental pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Ermias Mergia TerefeDepartment of Pharmacology and Pharmacognosy, United States International University-Africa, Nairobi, Kenya.ORCID 0000-0003-0630-8228
Faith Apolot OkaleboDepartment of Pharmacology and Pharmacognosy, University of Nairobi, Nairobi, Kenya.
Solomon DereseDepartment of Chemistry, University of Nairobi, Nairobi, Kenya.ORCID 0000-0002-2640-3583
Joseph MuriukiCentre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya.
Gaber El-Saber BatihaDepartment of Pharmacology and Therapeutics, Damanhour University, Damanhour, AlBeheira, 22511, Egypt.
University of Nairobi · KEAlliant International University · USDamanhour University · EGKenya Medical Research Institute · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman immunodeficiency virus (HIV) affects the body's defense mechanisms and leads to a number of opportunistic infections which later cause fatality as a result of an acquired immunodeficiency syndrome (AIDS). More than half a million individuals have lost their life in 2020 due to this disease. Antiretroviral drugs have played a great role in improving the quality of life of HIV infected individuals. The side effects of these drugs coupled with resistance of the virus to the various regimens, necessitates the search for potentially new and effective antiretroviral medication. The objective of this study is to evaluate anti-HIV activity of crude extracts of three

methodsAs part of our effort in screening anti-HIV medications, we evaluated the cytotoxicity and anti-HIV activity of three

resultsBased on our findings, the crude aerial part extract of

conclusionOut of five extracts from three

Indexed as

antiviral activityCroton dichogamusCroton macrostachyusCroton megalocarpuscytotoxicityHIVMT-4 cells

Identifiers

PMID35221732
PMCPMC8866981
OpenAlexW4200475741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.