Evidence map›Paper›PMID 35221452›Full record

ArticleBiocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al2022

New paradigms in regenerative engineering: Emerging role of extracellular vesicles paired with instructive biomaterials.

W Benton Swanson, Yuji Mishina

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Novel approaches for periodontal tissue engineering.Genesis (New York, N.Y. : 2000) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

W Benton SwansonDepartment of Biologic and Materials Science & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.
Yuji MishinaDepartment of Biologic and Materials Science & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.
University of Michigan–Ann Arbor · US

Funding

Regenerating cranial suture (Jaylynn Jones)R01DE027662 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HATCH, NAN E, MISHINA, YUJI · 2018 to 2022
$2.6M
Exosome-mediated Craniofacial Bone Tissue Engineering by Controlled ReleaseF30DE029359 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, WILLIAM BENTON · 2020 to 2024
$231k
NIDCR NIH HHS F30 DE029359NIDCR NIH HHS R01 DE027662
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve patient outcomes through efficient therapeutic strategies resulting in predictable patient outcomes.

Indexed as

BiomaterialsExtracellular vesiclesMesenchymal stem cellsRegenerative medicineTissue engineering

Identifiers

PMID35221452
PMCPMC8881001
OpenAlexW4210836778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.