ArticleSudanese journal of paediatrics2021
COVID-19 infection in a Down syndrome child.
Article in Sudanese journal of paediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- COVID-19 in patients with Down syndrome: A systematic review.Immunity, inflammation and disease · 2024Pooled it
- Clinical characteristics and comorbidities of COVID-19 in unvaccinated patients with Down syndrome: first year report in Brazil.Human genetics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical spectrum of COVID-19 infection varies from asymptomatic to critical illness. In children, it is usually asymptomatic or milder in severity. Younger infants and children with underlying medical illnesses are more prone to develop severe diseases. Fever and cough are common presentations in children. Angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2 are key proteins in the cell entry process of the virus in the gastrointestinal (GI) tract. Children with Down syndrome (DS) have increase mortality rates from COVID-19 compared to the general pediatric population. We are reporting a case of a DS baby with COVID-19 infection who presented with GI manifestations leading to hypernatremic dehydration with multiorgan dysfunction syndrome.
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Registered trials
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