Evidence map›Paper›PMID 35221334›Full record

ArticleNature cancer2022

Radiation exposure elicits a neutrophil-driven response in healthy lung tissue that enhances metastatic colonization.

Emma Nolan, Victoria Louise Bridgeman, Luigi Ombrato, Adam Karoutas, Nicolas Rabas, Celine Angeli Natascha Sewnath, Marcos Vasquez, Felipe Silva Rodrigues, Stuart Horswell, Peter Faull and 2 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

  1. Pooled it
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  11. Type I interferons induced upon respiratory viral infection impair lung metastatic initiation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Review
  13. Article
  14. Review
  15. A Novel Self-Regulated, Non-Directional Magnetic Thermos-BrachytherapyAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Article
  17. Article
  18. Targeting gut microbiota and metabolites in cancer radiotherapy.Clinical and translational medicine · 2025
    Review
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Emma NolanTumour Host Interaction laboratory, The Francis Crick Institute, London, UK.
Victoria Louise BridgemanTumour Host Interaction laboratory, The Francis Crick Institute, London, UK.
Luigi Ombrato *Tumour Host Interaction laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0002-1472-5980
Adam Karoutas *Tumour Host Interaction laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-4264-8203
Nicolas Rabas *Tumour Host Interaction laboratory, The Francis Crick Institute, London, UK.
Celine Angeli Natascha SewnathTumour Host Interaction laboratory, The Francis Crick Institute, London, UK.
Marcos VasquezCancer Immunology Unit, UCL Cancer Institute, University College London, London, UK.
Felipe Silva RodriguesTumour Host Interaction laboratory, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2139-8161
Stuart HorswellBioinformatics & Biostatistics Unit, The Francis Crick Institute, London, UK.ORCID http://orcid.org/0000-0003-2787-1933
Peter FaullProteomics Unit, The Francis Crick Institute, London, UK.
Rebecca CarterPreclinical Radiotherapy TTP, CRUK-City of London Centre, UCL Cancer Institute, University College London, London, UK.
Ilaria MalanchiTumour Host Interaction laboratory, The Francis Crick Institute, London, UK. Ilaria.Malanchi@crick.ac.uk.ORCID http://orcid.org/0000-0003-4867-3311
The Francis Crick Institute · GBCRUK Lung Cancer Centre of Excellence · GBQueen Mary University of London · GB

Funding

Cancer Research UK 28990Cancer Research UK C7893/A28990Cancer Research UK FC001112European Research Council 725492Medical Research Council FC001112Wellcome Trust FC001112
6 · The paper itself

Abstract

Radiotherapy is one of the most effective approaches to achieve tumor control in cancer patients, although healthy tissue injury due to off-target radiation exposure can occur. In this study, we used a model of acute radiation injury to the lung, in the context of cancer metastasis, to understand the biological link between tissue damage and cancer progression. We exposed healthy mouse lung tissue to radiation before the induction of metastasis and observed a strong enhancement of cancer cell growth. We found that locally activated neutrophils were key drivers of the tumor-supportive preconditioning of the lung microenvironment, governed by enhanced regenerative Notch signaling. Importantly, these tissue perturbations endowed arriving cancer cells with an augmented stemness phenotype. By preventing neutrophil-dependent Notch activation, via blocking degranulation, we were able to significantly offset the radiation-enhanced metastases. This work highlights a pro-tumorigenic activity of neutrophils, which is likely linked to their tissue regenerative functions.

Indexed as

Lung NeoplasmsRadiation ExposureAnimalsHumansLungMiceNeutrophil ActivationNeutrophilsTumor Microenvironment

Identifiers

PMID35221334
PMCPMC7612918
OpenAlexW4214590156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.