Observational studyAmerican journal of reproductive immunology (New York, N.Y. : 1989)2022
Does mRNA SARS-CoV-2 vaccine in the follicular fluid impact follicle and oocyte performance in IVF treatments?
Observational study in American journal of reproductive immunology (New York, N.Y. : 1989), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effect of female coronavirus disease 2019 vaccination on assisted reproductive outcomes: a systematic review and meta-analysis.Fertility and sterility · 2023Pooled it
- Pooled it
- Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature.Frontiers in endocrinology · 2022Pooled it
- Safety of COVID-19 vaccination in women undergoing IVF/ICSI treatment - Clinical study and systematic review.Frontiers in immunology · 2022Pooled it
- Endocrine disorders following SARS-CoV-2 vaccination: a comprehensive systematic review.Clinical and experimental vaccine research · 2026Article
- The influence of SARS-CoV-2 vaccination on in vitro fertilization outcomes.Human vaccines & immunotherapeutics · 2025Article
- Article
- Ovarian function after COVID-19: long-term effects and vaccine safety in ART patients.Journal of assisted reproduction and genetics · 2025Article
- Review
- Transcriptomic responses of cumulus granulosa cells to SARS-CoV-2 infection during controlled ovarian stimulation.Apoptosis : an international journal on programmed cell death · 2024Article
- SARS-CoV-2 Vaccination is Not Associated With Involuntary Childlessness in Female Healthcare Workers: A Multicenter Cohort Study.Influenza and other respiratory viruses · 2024Article
- The impact of SARS-CoV-2 mRNA vaccine on intracytoplasmic sperm injection outcomes at a fertility center in Iraq: A prospective cohort study.Health science reports · 2024Article
- The type of COVID-19 vaccination does not affect reproductive function and pregnancy outcomes in infertile couples.Frontiers in endocrinology · 2024Article
- Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review.Annals of medicine · 2023Review
- Association of Maternal Inactivated COVID-19 Vaccination within 3 Months before Conception with Neonatal Outcomes.Vaccines · 2023Article
- COVID-19 Vaccines and Assisted Reproductive Techniques: A Systematic Review.Journal of personalized medicine · 2023Review
- The Effect of COVID-19 Vaccine on Women's Reproductive Health: A Cross-Sectional Study.Cureus · 2023Article
- Female reproduction and abnormal uterine bleeding after COVID-19 vaccination.Clinical and experimental reproductive medicine · 2023Article
- "GONE WITH THE WIND": The Transitory Effects of COVID-19 on the Gynecological System.Journal of personalized medicine · 2023Review
- COVID-19 vaccine uptake and hesitation among men and women preparing for pregnancy: a cross-section survey based on the theory of planned behavior.BMC public health · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
problemThe COVID-19 pandemic has many clinical manifestations. Rapid vaccine development raised concerns and speculations about future fertility outcomes and vaccine safety. We evaluated the effect of Pfizer-BioNTech mRNA SARS-CoV-2 vaccine on IVF treatment, oocyte and embryo quality, and pregnancy outcomes. METHOD OF STUDY: This prospective, observational cohort study was conducted in a referral IVF Unit, 3/2021-5/2021. We aimed to recruit all women undergoing IVF/ICSI cycles from 3/1-4/30/2021, 2-8 weeks after the second vaccination, and to analyze 50-60 samples in the 2-month period. Patients were categorized according to serum antibody levels: positive for spike (S), positive for nucleotide (N), or negative for both. On the day of ovum pick-up, follicular fluid and blood samples were analyzed for anti-nucleotide (anti-N) antibodies, and anti-spike (anti-S) antibodies, hormonal profile, C-reactive protein (CRP) and other metabolic parameters.
resultsOf 59 women enrolled, 37 reported being vaccinated and 22 were not. We found 97% correlation between anti-S and anti-N in the blood and the follicular fluid. Follicular fluid was analyzed based on antibody categorization. All IVF treatment parameters in the follicular fluids and serum were comparable, except CRP was significantly elevated among patients with anti-N antibodies (2.29 [1.42-6.08] vs. 4.11 [1.62-5.75] vs. 1.44 [.36-8.33]; p < .001). Pregnancy outcomes were comparable (44% vs. 33% vs. 50%; p = .97).
conclusionmRNA SARS-CoV-2 vaccine did not appear to affect treatment outcomes or ovarian reserves in the subsequent IVF cycle.
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