Evidence map›Paper›PMID 35220550›Full record

ArticlePain and therapy2022

Abnormalities of Thalamic Functional Connectivity in Patients with Migraine: A Resting-State fMRI Study.

Zi-Min Cao, Yi-Chao Chen, Guo-Yun Liu, Xu Wang, An-Qi Shi, Lu-Fan Xu, Zhi-Jun Li, Jian-Wei Huo, Ya-Nan Zhang, Ni Liu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Aberrant Spontaneous Low-Frequency Brain Activity in Migraine: A Meta-Analysis of Resting-State fMRI Studies.Journal of neuroimaging : official journal of the American Society of Neuroimaging
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Zi-Min CaoDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
Yi-Chao ChenDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
Guo-Yun LiuDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
Xu WangDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
An-Qi ShiDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
Lu-Fan XuDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
Zhi-Jun LiDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China.
Jian-Wei HuoDepartment of Radiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing, 100010, China.
Ya-Nan ZhangDepartment of Radiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing, 100010, China.
Ni LiuDepartment of Radiology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, 23 Meishuguanhou Street, Dongcheng District, Beijing, 100010, China.
Chao-Qun YanDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China. yanchaoqun857@126.com.ORCID http://orcid.org/0000-0001-7921-3057
Jun WangDepartment of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip, Dongcheng District, Beijing, 100700, China. wangjunee@yeah.net.
Beijing University of Chinese Medicine · CNCapital Medical University · CN

Funding

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China 82004197Project for new teachers of Beijing University of Chinese Medicine 2020-JYB-XJSJJ-045
6 · The paper itself

Abstract

introductionMigraine is a common headache disorder. Many studies have used magnetic resonance imaging (MRI) to explore the possible pathogenesis of migraine, but they have not reached consistent conclusions and lack rigorous multiple comparison correction. Thus, this study investigates the mechanisms of migraine development from the perspective of altered functional connectivity (FC) in brain regions by using data-driven and regions of interest (ROI)-based approaches.

methodsResting-state functional MRI data were collected from 30 patients with migraine and 40 healthy controls (HCs) matched for age, gender, and years of education. For the data-driven method, we used a voxel-mirrored homotopic connectivity (VMHC) approach to compare the FC between the patients and HCs. For the ROI-based method, significant differences in VMHC maps between the patients and HCs were defined as ROI. The seed-based approach further revealed significant differences in FC between the seeds and the other brain regions. Furthermore, the correlations between abnormal FC and clinical characteristics of patients were investigated. A rigorous multiple comparison correction was used with false discovery rate and permutation test (5000 times).

resultsIn comparison with the controls group, patients showed enhanced VMHC in the bilateral thalamus. We also observed enhanced FC between the left thalamus and the left superior frontal gyrus, and increased FC between the right thalamus and the left middle frontal gyrus (Brodmann area 45 and Brodmann area 8) in patients. Further analysis showed that the FC values in the left superior frontal gyrus and left middle frontal gyrus were negatively corrected with visual analogue scale scores or attack times for headaches.

conclusionsPatients with migraine showed altered VMHC in the bilateral thalamus, and abnormal FC of bilateral thalamus and other brain regions. The abnormalities in thalamic FC are a likely mechanism for the development of migraine.

trial registrationChinese Clinical Trial Registry, ChiCTR2000033995. Registered on 20 June 2020.

Indexed as

fMRIFunctional connectivityMigraineThalamusVoxel-mirrored homotopic connectivity

Identifiers

PMID35220550
PMCPMC9098714
OpenAlexW4214536948

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.