Evidence map›Paper›PMID 35220458›Full record

ArticlePediatric surgery international2022

Long-term outcomes following failure of Nissen fundoplication.

Debasish B Banerjee, Pooja Parekh, Kate Cross, Simon Blackburn, Derek J Roebuck, Joe Curry, Simon Eaton, Premal A Patel, Paolo De Coppi

Abstract read
PubMed Publisher
In one paragraph

Article in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Debasish B BanerjeeGreat Ormond Street Hospital NHS Foundation Trust, London, UK. debasishbanerjee24@yahoo.co.uk.
Pooja ParekhGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
Kate CrossGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
Simon BlackburnGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
Derek J RoebuckGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
Joe CurryGreat Ormond Street Hospital NHS Foundation Trust, London, UK.
Simon EatonUCL Great Ormond Street Institute of Child Health, London, UK.
Premal A PatelUCL Great Ormond Street Institute of Child Health, London, UK.
Paolo De CoppiUCL Great Ormond Street Institute of Child Health, London, UK.
Great Ormond Street Hospital for Children NHS Foundation Trust · GBUniversity College London · GBGreat Ormond Street Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the management and outcomes of patients with gastro-oesophageal reflux (GOR) that requires further intervention following failure of Nissen fundoplication (NF).

methodsAfter institutional audit department approval, a retrospective review of paediatric patients who had further intervention following failure of primary NF between January 2006 and December 2015 for GOR at our centre was performed. Data are presented as median (range).

resultsOf 820 patients who underwent NF, 190 (23%) received further procedures for GOR management at a median of 21 months of age (6-186); 90/190 (47%) had gastro-jejunal feeding (GJ). Of these, 67 (74%) remained on GJ feeds up to a median of 48 months and 23/90 (26%) had a second NF after GJ feeding. 97/190 (51%) had a redo fundoplication without having had a GJ; thus, 120/190 (63%) of patients having a further procedure went on to have a second NF after a median period of 15 months (1-70 months). Three patients (2%) had early emergency wrap revision 4 days after first fundoplication (we classed this as an 'early complication'). Of the seven patients who failed a 3rd NF, 4 continued GJ feeding, 2 of had oesophagogastric dissociation; 2 had 4th NF of which 1 was successful and 1 patient had gastric pacemaker and is successfully feeding orally. Patients who were finally successfully managed with GJ underwent 2 (2-5) tube changes/year. We found patients who had a previous GJ were more likely to have failure of the redo fundoplication than those who had not to have the GJ (16/24 vs. 30/90, p = 0.005).

conclusionThe chance of success decreases with every further attempt at fundoplication. The only factor significantly associated with failure of redo fundoplication was whether the patient previously had a GJ tube. In patients with failed fundoplications, when symptom free on jejunal feedings, further anti-reflux surgical intervention should be avoided. A randomized prospective study is needed for patient selection.

Indexed as

Gastroesophageal RefluxLaparoscopyChildFundoplicationHumansRecurrenceReoperationRetrospective StudiesGastro-jejunal feedingGastro-oesophageal reflux diseaseNissen fundoplicationRedo fundoplication

Identifiers

PMID35220458
OpenAlexW4214579613

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.