Evidence map›Paper›PMID 35220456›Full record

ArticleAdvances in biochemical engineering/biotechnology2022

Developing Synthetic Methylotrophs by Metabolic Engineering-Guided Adaptive Laboratory Evolution.

Yu Wang, Ping Zheng, Jibin Sun

Abstract read
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In one paragraph

Article in Advances in biochemical engineering/biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu WangKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences; National Technology Innovation Center of Synthetic Biology, Tianjin, China. wang_y@tib.cas.cn.
Ping ZhengKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences; National Technology Innovation Center of Synthetic Biology, Tianjin, China.
Jibin SunKey Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences; National Technology Innovation Center of Synthetic Biology, Tianjin, China. sun_jb@tib.cas.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methanol is a promising alternative feedstock for biomanufacturing. However, natural platform industrial microorganisms such as Escherichia coli and Corynebacterium glutamicum cannot assimilate methanol. Although some methanol assimilation pathways differ from the typical sugar metabolism by only a few enzymes, engineering platform microorganisms to efficiently utilize methanol is very challenging. Recent advances in creating the first methylotrophic E. coli growing solely on methanol have underscored the value of metabolic engineering-guided adaptive laboratory evolution (ME-ALE) in developing non-natural methanol utilizers. This chapter reviews the recent progress in engineering platform microorganisms to utilize methanol by ME-ALE and discusses the future challenges in developing superior synthetic methylotrophs for methanol-based biomanufacturing.

Indexed as

Corynebacterium glutamicumMetabolic EngineeringEscherichia coliMethanolMethanolAdaptive laboratory evolutionCorynebacterium glutamicumEscherichia coliFormaldehydeMetabolic engineeringMethanolSynthetic methylotroph

Identifiers

PMID35220456

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.