ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- A cortical insula-orbitofrontal circuit drives stress-induced dopamine system dysfunction.Molecular psychiatry · 2026Article
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- Estrogen Replacement Therapy in Ovariectomized Rats: Complementary Roles of ER and GPR30 in Alleviating Depressive-like Behavior.Current issues in molecular biology · 2026Article
- Article
- Alcohol Attenuates CRF-Induced Excitatory Effects from the Extended Amygdala to Dorsostriatal Cholinergic Interneurons.bioRxiv : the preprint server for biology · 2025Article
- Exposure to early-life stress uncovers shared biological signatures underlying vulnerability in the habenula and insular cortex of male and female adult rats.Neurobiology of stress · 2025Article
- Insular input to the prelimbic cortex underlies social affective behavior in rats.bioRxiv : the preprint server for biology · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.Research square · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.bioRxiv : the preprint server for biology · 2025Article
- Melanin-concentrating hormone and orexin shape social affective behavior via action in the insular cortex of rat.Psychopharmacology · 2025Article
- Pre-pandemic brain structure and COVID-19 fear: insights into posttraumatic stress and general distress.Frontiers in psychiatry · 2025Article
- A population of Insula neurons encodes for social preference only after acute social isolation in mice.Nature communications · 2024Article
- Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice.Nature communications · 2024Article
- Pharmacological Manipulation of Corticotropin-Releasing Factor Receptors in the Anterior and Posterior Subregions of the Insular Cortex Differently Affects Anxiety-Like Behaviors in the Elevated Plus Maze in Rats.BioMed research international · 2024Article
- Proteomic Analysis of the Amygdala Reveals Dynamic Changes in Glutamate Transporter-1 During Progression of Complete Freund's Adjuvant-Induced Pain Aversion.Molecular neurobiology · 2023Article
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
- Article
- Maternal immune activation alters social affective behavior and sensitivity to corticotropin releasing factor in male but not female rats.Hormones and behavior · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.bioRxiv : the preprint server for biology · 2023Article
- Article
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7 authors at 2 institutions in 1 country.
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Abstract
Impairments in identifying and responding to the emotions of others manifest in a variety of psychopathologies. Therefore, elaborating the neurobiological mechanisms that underpin social responses to social emotions, or social affective behavior, is a translationally important goal. The insular cortex is consistently implicated in stress-related social and anxiety disorders, which are associated with diminished ability to make and use inferences about the emotions of others to guide behavior. We investigated how corticotropin-releasing factor (CRF), a neuromodulator evoked upon exposure to stressed conspecifics, influenced the insula. We hypothesized that social affective behavior requires CRF signaling in the insular cortex in order to detect stress in social interactions. In acute slices from male and female rats, CRF depolarized insular pyramidal neurons. In males, but not females, CRF suppressed presynaptic GABAergic inhibition leading to greater excitatory synaptic efficacy in a CRF receptor 1 (CRF
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.