Evidence map›Paper›PMID 35220405›Full record

ArticleTranslational psychiatry2022

Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder.

Chenyao Wang, Shin-Ichiro Horigane, Minoru Wakamori, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. CACNA1D-Related Channelopathies: From Hypertension to Autism.Handbook of experimental pharmacology · 2023
    Review
  4. CACNA1C (CaNeuropharmacology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Chenyao Wang *Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Shin-Ichiro Horigane *Department of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Minoru Wakamori *Department of Oral Biology, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Shuhei UedaDepartment of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.ORCID http://orcid.org/0000-0001-8107-8608
Takeshi KawabataProtein Research Foundation, Osaka, Japan.
Hajime FujiiDepartment of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Itaru KushimaDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-0018-5178
Hiroki KimuraDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Kanako IshizukaDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0003-0747-7269
Yukako NakamuraDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yoshimi IwayamaLaboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan.
Masashi IkedaDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.ORCID http://orcid.org/0000-0001-6237-2449
Nakao IwataDepartment of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.ORCID http://orcid.org/0000-0003-3189-6076
Takashi OkadaDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0001-5580-9913
Branko AleksicDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan. branko@med.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0001-8982-4580
Daisuke MoriDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-9072-2546
Takashi YoshidaDepartment of Oral Biology, Graduate School of Dentistry, Tohoku University, Sendai, Japan.
Haruhiko BitoDepartment of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6315-9594
Takeo YoshikawaLaboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0003-2791-6679
Sayaka Takemoto-KimuraDepartment of Neuroscience I, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan. stakemoto@riem.nagoya-u.ac.jp.ORCID http://orcid.org/0000-0002-2190-3191
Norio OzakiDepartment of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID http://orcid.org/0000-0002-7360-4898
Nagoya University · JPFujita Health University · JPRIKEN Center for Brain Science · JPThe University of Tokyo · JPTohoku University · JPNagoya Industrial Science Research Institute · JPUbe Frontier University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several large-scale whole-exome sequencing studies in patients with schizophrenia (SCZ) and autism spectrum disorder (ASD) have identified rare variants with modest or strong effect size as genetic risk factors. Dysregulation of cellular calcium homeostasis might be involved in SCZ/ASD pathogenesis, and genes encoding L-type voltage-gated calcium channel (VGCC) subunits Ca

Indexed as

Autism Spectrum DisorderSchizophreniaAsian PeopleGene FrequencyGenetic Predisposition to DiseaseHumansJapan

Identifiers

PMID35220405
PMCPMC8882172
OpenAlexW4214586804

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.