Evidence map›Paper›PMID 35220296›Full record

ArticleInternational journal of stem cells2022

Generation of Highly Expandable Intestinal Spheroids Composed of Stem Cells.

Ohman Kwon, Won Dong Yu, Ye Seul Son, Kwang Bo Jung, Hana Lee, Mi-Young Son

Open access · diamondAbstract read
In one paragraph

Article in International journal of stem cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Emerging advances in intestinal models for in vitro preclinical research.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Lo and Behold, the Lab-Grown Organs Have Arrived!International journal of stem cells · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ohman KwonKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
Won Dong YuKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
Ye Seul SonKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
Kwang Bo JungKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
Hana LeeKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
Mi-Young SonKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
Korea Research Institute of Bioscience and Biotechnology · KRKorea University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many of early findings regarding intestinal stem cells (ISCs) and their niche in the human intestine have relied on colorectal cancer cell lines and labor-intensive and time-consuming mouse models. However, these models cannot accurately recapitulate the physiologically relevant aspects of human ISCs. In this study, we demonstrate a reliable and robust culture method for 3D expanding intestinal spheroids (InS

Indexed as

Expandable Intestinal spheroid (InSHuman intestinal organoid (HIO)Intestinal stem cellMaturity memoryWNT pathway

Identifiers

PMID35220296
PMCPMC8889332
OpenAlexW4214507485

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.