ArticleThrombosis research2022
Deaths related to pulmonary embolism and cardiovascular events before and during the 2020 COVID-19 pandemic: An epidemiological analysis of data from an Italian high-risk area.
Article in Thrombosis research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
- Mortality Related to Different Circulatory Diseases Before, During and After the COVID-19 Pandemic.Clinical cardiology · 2026Article
- The Covid-19 pandemic as an inflection point in US mortality trends from hematologic and circulatory system diseases: a piecewise trend analysis.BMC public health · 2026Article
- Prevalence and effects of pulmonary embolism on hospital outcomes among COVID-19 patients.BMC research notes · 2025Article
- Gender disparity in clinical and management outcomes in patients with pulmonary embolism: a systematic review and meta-analysis.Proceedings (Baylor University. Medical Center) · 2025Article
- Risk factors for mortality in hospitalized COVID-19 patients across five waves in Pakistan.Scientific reports · 2024Article
- Intensive care treatment in acute pulmonary embolism in Germany, 2016 to 2020: a nationwide inpatient database study.Research and practice in thrombosis and haemostasis · 2024Article
- Epidemiology, Etiology, and Pathophysiology of Pulmonary Embolism.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024Review
- Diabetes Mellitus and Its Association with Adverse In-Hospital Outcomes in Patients with COVID-19-A Nationwide Study.Viruses · 2023Article
- COVID-19 infection and its impact on case fatality in patients with pulmonary embolism.The European respiratory journal · 2023Article
- Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19.Frontiers in immunology · 2023Article
- Predisposing factors for admission to intensive care units of patients with COVID-19 infection-Results of the German nationwide inpatient sample.Frontiers in public health · 2023Article
- Temporal Trends in Patients with Peripheral Artery Disease Influenced by COVID-19 Pandemic.Journal of clinical medicine · 2022Article
- Annual Mortality Related to Pulmonary Embolism in the U.S. Before and During the COVID-19 Pandemic.Journal of the American College of Cardiology · 2022Article
- Mortality Related to Chronic Obstructive Pulmonary Disease during the COVID-19 Pandemic: An Analysis of Multiple Causes of Death through Different Epidemic Waves in Veneto, Italy.International journal of environmental research and public health · 2022Article
- Diabetes as a cause of death across different COVID-19 epidemic waves.Diabetes research and clinical practice · 2022Article
- Pulmonary Embolism in Women: A Systematic Review of the Current Literature.Journal of cardiovascular development and disease · 2022Review
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11 authors at 5 institutions in 4 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary embolism is a known complication of coronavirus disease 2019 (COVID-19). Epidemiological population data focusing on pulmonary embolism-related mortality is limited.
methodsVeneto is a region in Northern Italy counting 4,879,133 inhabitants in 2020. All ICD-10 codes from death certificates (1st January 2018 to 31st December 2020) were examined. Comparisons were made between 2020 (COVID-19 outbreak) and the average of the two-year period 2018-2019. All-cause, COVID-19-related and the following cardiovascular deaths have been studied: pulmonary embolism, hypertensive disease, ischemic heart disease, atrial fibrillation/flutter, and cerebrovascular diseases.
resultsIn 2020, a total of 56,412 deaths were recorded, corresponding to a 16% (n = 7806) increase compared to the period 2018-2019. The relative percentage increase during the so-called first and second waves was 19% and 44%, respectively. Of 7806 excess deaths, COVID-19 codes were reported in 90% of death certificates. The percentage increase in pulmonary embolism-related deaths was 27% (95%CI 19-35%), 1018 deaths during the year 2020, compared to 804 mean annual deaths in the period 2018-2019. This was more evident among men, who experience an absolute increase of 147 deaths (+45%), than in women (+67 deaths; +14%). The increase was primarily driven by deaths recorded during the second wave (+91% in October-December). An excess of deaths, particularly among men and during the second wave, was also observed for other cardiovascular diseases, notably hypertensive disease, atrial fibrillation, cerebrovascular disease, and ischemic heart disease.
conclusionsWe observed a considerable increase of all-cause mortality during the year 2020. This was mainly driven by COVID-19 and its complications. The relative increase in the number of pulmonary embolism-related deaths was more prominent during the second wave, suggesting a possible underdiagnosis during the first wave.
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